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Procarbazine

Prescription

Alkylating Agent / MOPP Component (Chemotherapy)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

2 available

Interactions

2 documented

Formulations

Mechanism of action

Methylhydrazine derivative that is oxidized intracellularly to form alkylating metabolites that crosslink DNA. Also inhibits DNA, RNA, and protein synthesis. Component of MOPP protocol for lymphoma rescue.

At a glance

Class

Alkylating Agent / MOPP Component (Chemotherapy)

Schedule

Prescription (Chemotherapy)

Storage

Store at room temperature 15–30°C; protect from moisture and excessive heat; chemotherapy precautions

Dosing

🐕

Dog

Used as rescue protocol for refractory lymphoma (MOPP)

Dose

—

Route

Frequency

q24h for 14 days per cycle

🐈

Cat

Rarely used in cats

Dose

25–50 mg/m²

Route

Frequency

q24h x 14 days

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Store at room temperature 15–30°C; protect from moisture and excessive heat; chemotherapy precautions

Safety

Monitoring parameters

CBC at nadir (day 14–21)Neurological assessmentHepatic enzymes

Educational reference only

Interactions

Contraindicated — 2

Tramadol

contraindicated

Procarbazine has MAO inhibitor activity. Tramadol is a serotonin reuptake inhibitor. Combined: serotonin syndrome.

Management: NEVER combine. Use non-serotonergic analgesic during procarbazine (MOPP) chemotherapy.

Fluoxetine

contraindicated

Procarbazine (MAOI activity) + SSRI: serotonin syndrome.

Management: NEVER combine. Discontinue SSRI with adequate washout before MOPP protocol.

Educational reference only

Brands

Other markets

Matulane

Natulan

FAQs

Frequently asked questions

›What is Procarbazine?

Procarbazine is a alkylating agent / mopp component (chemotherapy) used in pets. Methylhydrazine derivative that is oxidized intracellularly to form alkylating metabolites that crosslink DNA. Also inhibits DNA, RNA, and protein synthesis. Component of MOPP protocol for lymphoma rescue.

›What is Procarbazine used for in pets?

Procarbazine is used in veterinary medicine for: Used as rescue protocol for refractory lymphoma (MOPP); Rarely used in cats.

›What is the Procarbazine dose for dogs?

For dogs, Procarbazine is typically dosed as follows — Used as rescue protocol for refractory lymphoma (MOPP): undefined undefined PO q24h for 14 days per cycle. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Procarbazine dose for cats?

For cats, Procarbazine is typically dosed as follows — Rarely used in cats: 25–50 mg/m² PO q24h x 14 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Procarbazine need a prescription?

Yes. Procarbazine is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database