Dual-targeting fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV with equal potency (dual-target inhibition), reducing resistance development. Broader spectrum than enrofloxacin/marbofloxacin including enhanced anaerobic coverage.
At a glance
Class
Third-Generation Veterinary Fluoroquinolone
Storage
Oral suspension at room temperature; use within 3 months of opening
Dosing
FDA-approved (US) for feline skin infections and wounds
Safety
Clinical responseRetinal exam in cats with prolonged useCulture and sensitivity
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Pradofloxacin?
Pradofloxacin is a third-generation veterinary fluoroquinolone used in pets. Dual-targeting fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV with equal potency (dual-target inhibition), reducing resistance development. Broader spectrum than enrofloxacin/marbofloxacin including enhanced anaerobic coverage.
›What is Pradofloxacin used for in pets?
Pradofloxacin is used in veterinary medicine for: EU-approved for dogs; FDA-approved (US) for feline skin infections and wounds.
›What is the Pradofloxacin dose for dogs?
For dogs, Pradofloxacin is typically dosed as follows — EU-approved for dogs: 3–4.5 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Pradofloxacin dose for cats?
For cats, Pradofloxacin is typically dosed as follows — FDA-approved (US) for feline skin infections and wounds: 5 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Pradofloxacin need a prescription?
Yes. Pradofloxacin is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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