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Polyethylene Glycol 3350 (PEG 3350)

Osmotic Laxative
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
3

Mechanism of action

Large polymer that is not absorbed or metabolized in the GI tract. Creates osmotic gradient retaining water in the colonic lumen, softening stool and increasing fecal volume, promoting defecation. Does not cause electrolyte disturbances at standard doses.

At a glance

Class
Osmotic Laxative
Schedule
OTC
Storage
Store at room temperature below 30°C

Dosing

🐕

Dog

Used for constipation and bowel prep
Dose
Route
PO (mixed in food, water)
Frequency
q12–24h
🐈

Cat

Used for feline constipation and megacolon management
Dose
Route
PO
Frequency
q12–24h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 3

Strength
Strength
Strength

Storage

Store at room temperature below 30°C

Safety

Monitoring parameters

Stool frequency and consistencyHydration statusElectrolytes with prolonged high-dose use
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

MiraLAX
GoLYTELY (with electrolytes)

FAQs

Frequently asked questions

What is Polyethylene Glycol 3350 (PEG 3350)?
Polyethylene Glycol 3350 (PEG 3350) is a osmotic laxative used in pets. Large polymer that is not absorbed or metabolized in the GI tract. Creates osmotic gradient retaining water in the colonic lumen, softening stool and increasing fecal volume, promoting defecation. Does not cause electrolyte disturbances at standard doses.
What is Polyethylene Glycol 3350 (PEG 3350) used for in pets?
Polyethylene Glycol 3350 (PEG 3350) is used in veterinary medicine for: Used for constipation and bowel prep; Used for feline constipation and megacolon management.
What is the Polyethylene Glycol 3350 (PEG 3350) dose for dogs?
For dogs, Polyethylene Glycol 3350 (PEG 3350) is typically dosed as follows — Used for constipation and bowel prep: undefined undefined PO (mixed in food/water) q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Polyethylene Glycol 3350 (PEG 3350) dose for cats?
For cats, Polyethylene Glycol 3350 (PEG 3350) is typically dosed as follows — Used for feline constipation and megacolon management: undefined undefined PO q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Polyethylene Glycol 3350 (PEG 3350) need a prescription?
Polyethylene Glycol 3350 (PEG 3350) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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