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Pentosan Polysulfate Sodium

Prescription
Semi-Synthetic Polysaccharide / Chondroprotective Agent
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
2

Mechanism of action

Heparin-like polysaccharide that inhibits fibronectin and fibrinogen binding to cartilage surfaces, stimulates proteoglycan synthesis by chondrocytes, inhibits metalloproteinases, and has anti-inflammatory effects. Also used for idiopathic cystitis (bladder glycosaminoglycan layer restoration).

At a glance

Class
Semi-Synthetic Polysaccharide / Chondroprotective Agent
Schedule
Prescription
Storage
Injectable refrigerated 2–8°C; oral capsules at room temperature below 30°C

Dosing

🐕

Dog

Disease-modifying OA drug (DMOAD)
Dose
Route
SQ (Cartrophen), PO (Elmiron)
Frequency
Weekly x 4, then monthly (OA); q24h (cystitis)
🐈

Cat

Feline idiopathic cystitis (FIC) treatment — helps restore bladder glycosaminogl
Dose
3 mg/kg
Route
SQ, PO
Frequency
Weekly x 4 (OA); q24h (cystitis)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Injectable refrigerated 2–8°C; oral capsules at room temperature below 30°C

Safety

Monitoring parameters

Pain/lameness scores monthlyCoagulation parameters in at-risk patientsUrinary signs (cystitis)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Elmiron
Cartrophen Vet
Zydax

FAQs

Frequently asked questions

What is Pentosan Polysulfate Sodium?
Pentosan Polysulfate Sodium is a semi-synthetic polysaccharide / chondroprotective agent used in pets. Heparin-like polysaccharide that inhibits fibronectin and fibrinogen binding to cartilage surfaces, stimulates proteoglycan synthesis by chondrocytes, inhibits metalloproteinases, and has anti-inflammatory effects. Also used for idiopathic cystitis (bladder glycosaminoglycan layer restoration).
What is Pentosan Polysulfate Sodium used for in pets?
Pentosan Polysulfate Sodium is used in veterinary medicine for: Disease-modifying OA drug (DMOAD); Feline idiopathic cystitis (FIC) treatment — helps restore bladder glycosaminogl.
What is the Pentosan Polysulfate Sodium dose for dogs?
For dogs, Pentosan Polysulfate Sodium is typically dosed as follows — Disease-modifying OA drug (DMOAD): undefined undefined SQ (Cartrophen)/PO (Elmiron) Weekly x 4, then monthly (OA); q24h (cystitis). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Pentosan Polysulfate Sodium dose for cats?
For cats, Pentosan Polysulfate Sodium is typically dosed as follows — Feline idiopathic cystitis (FIC) treatment — helps restore bladder glycosaminogl: 3 mg/kg SQ/PO Weekly x 4 (OA); q24h (cystitis). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Pentosan Polysulfate Sodium need a prescription?
Yes. Pentosan Polysulfate Sodium is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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