Binds to ergosterol in fungal cell membranes, creating pores that increase membrane permeability, leading to leakage of intracellular contents and cell death
At a glance
Storage
Below 25°C, protect from light and moisture
Dosing
Oral and GI candidiasis, topical fungal infections
Max dose
500000 IU/dose; 2000000 IU/day
Duration: 7–14 days or until resolved
Oral and GI candidiasis
Max dose
500000 IU/dose; 2000000 IU/day
Duration: 7–14 days or until resolved
Safety
Absolute contraindications — do not use
Adverse effects
Serious
Hypersensitivity reactions (rare)
Clinical resolution of lesionsAppetite and GI signs
Interactions
No documented interactions.
Brands
International
Mycostatin
Bristol-Myers Squibb
Panalog (combination)
Novartis
India
Nystatin Oral Suspension
Glenmark
FAQs
Frequently asked questions
›What is Nystatin?
Nystatin is a polyene antifungal used in pets. Binds to ergosterol in fungal cell membranes, creating pores that increase membrane permeability, leading to leakage of intracellular contents and cell death
›What is Nystatin used for in pets?
Nystatin is used in veterinary medicine for: Oral and GI candidiasis, topical fungal infections; Oral and GI candidiasis.
›What is the Nystatin dose for dogs?
For dogs, Nystatin is typically dosed as follows — Oral and GI candidiasis, topical fungal infections: 22000–100000 IU/kg PO/topical TID to QID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Nystatin dose for cats?
For cats, Nystatin is typically dosed as follows — Oral and GI candidiasis: 22000–100000 IU/kg PO/topical TID to QID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Nystatin?
Common: GI upset, Vomiting, Diarrhea. Serious (call your vet immediately): Hypersensitivity reactions (rare).
›Does Nystatin need a prescription?
Yes. Nystatin is a prescription medication and should only be administered under veterinary supervision.
›When should Nystatin not be used?
Do not use Nystatin if: Hypersensitivity to nystatin.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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