Inhibits bacterial DNA gyrase B subunit (ATPase domain), blocking ATP hydrolysis required for DNA supercoiling. Different binding site from fluoroquinolones (gyrase A subunit). Active against staphylococci and some gram-negatives.
At a glance
Class
Aminocoumarin Antibiotic
Storage
Store at room temperature, protect from light
Dosing
Historically used in combination products for staphylococcal skin infections and
Safety
Hepatic enzymesCoagulation (PT)Clinical response
Interactions
No documented interactions.
Brands
Other markets
Albaplex (with tetracycline + prednisolone)
FAQs
Frequently asked questions
›What is Novobiocin?
Novobiocin is a aminocoumarin antibiotic used in pets. Inhibits bacterial DNA gyrase B subunit (ATPase domain), blocking ATP hydrolysis required for DNA supercoiling. Different binding site from fluoroquinolones (gyrase A subunit). Active against staphylococci and some gram-negatives.
›What is Novobiocin used for in pets?
Novobiocin is used in veterinary medicine for: Historically used in combination products for staphylococcal skin infections and; Limited feline data.
›What is the Novobiocin dose for dogs?
For dogs, Novobiocin is typically dosed as follows — Historically used in combination products for staphylococcal skin infections and: 10–22 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Novobiocin dose for cats?
For cats, Novobiocin is typically dosed as follows — Limited feline data: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Novobiocin need a prescription?
Yes. Novobiocin is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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