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Novobiocin

Prescription
Aminocoumarin Antibiotic
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
1

Mechanism of action

Inhibits bacterial DNA gyrase B subunit (ATPase domain), blocking ATP hydrolysis required for DNA supercoiling. Different binding site from fluoroquinolones (gyrase A subunit). Active against staphylococci and some gram-negatives.

At a glance

Class
Aminocoumarin Antibiotic
Schedule
Prescription
Storage
Store at room temperature, protect from light

Dosing

🐕

Dog

Historically used in combination products for staphylococcal skin infections and
Dose
10–22 mg/kg
Route
PO
Frequency
q12h
🐈

Cat

Limited feline data
Dose
Route
N, A
Frequency
N/A
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Store at room temperature, protect from light

Safety

Monitoring parameters

Hepatic enzymesCoagulation (PT)Clinical response
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Albaplex (with tetracycline + prednisolone)

FAQs

Frequently asked questions

What is Novobiocin?
Novobiocin is a aminocoumarin antibiotic used in pets. Inhibits bacterial DNA gyrase B subunit (ATPase domain), blocking ATP hydrolysis required for DNA supercoiling. Different binding site from fluoroquinolones (gyrase A subunit). Active against staphylococci and some gram-negatives.
What is Novobiocin used for in pets?
Novobiocin is used in veterinary medicine for: Historically used in combination products for staphylococcal skin infections and; Limited feline data.
What is the Novobiocin dose for dogs?
For dogs, Novobiocin is typically dosed as follows — Historically used in combination products for staphylococcal skin infections and: 10–22 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Novobiocin dose for cats?
For cats, Novobiocin is typically dosed as follows — Limited feline data: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Novobiocin need a prescription?
Yes. Novobiocin is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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