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Nizatidine

H2-Receptor Antagonist / Prokinetic
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
2

Mechanism of action

Competitively blocks histamine H2 receptors on parietal cells, reducing basal and stimulated gastric acid secretion. Unique among H2-blockers: also inhibits acetylcholinesterase, providing prokinetic effects (increases gastric motility).

At a glance

Class
H2-Receptor Antagonist / Prokinetic
Schedule
OTC
Storage
Store at room temperature below 25°C, protect from moisture

Dosing

🐕

Dog

Preferred H2-blocker when prokinetic effect is desired (gastroparesis with gastr
Dose
5–10 mg/kg
Route
PO
Frequency
q24h
🐈

Cat

Same dual acid-suppression/prokinetic benefit
Dose
2.5–5 mg/kg
Route
PO
Frequency
q24h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature below 25°C, protect from moisture

Safety

Monitoring parameters

GI symptom resolutionRenal function for dose adjustment
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Axid

FAQs

Frequently asked questions

What is Nizatidine?
Nizatidine is a h2-receptor antagonist / prokinetic used in pets. Competitively blocks histamine H2 receptors on parietal cells, reducing basal and stimulated gastric acid secretion. Unique among H2-blockers: also inhibits acetylcholinesterase, providing prokinetic effects (increases gastric motility).
What is Nizatidine used for in pets?
Nizatidine is used in veterinary medicine for: Preferred H2-blocker when prokinetic effect is desired (gastroparesis with gastr; Same dual acid-suppression/prokinetic benefit.
What is the Nizatidine dose for dogs?
For dogs, Nizatidine is typically dosed as follows — Preferred H2-blocker when prokinetic effect is desired (gastroparesis with gastr: 5–10 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Nizatidine dose for cats?
For cats, Nizatidine is typically dosed as follows — Same dual acid-suppression/prokinetic benefit: 2.5–5 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Nizatidine need a prescription?
Nizatidine is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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