Amide form of niacin (vitamin B3) with immunomodulatory properties: inhibits neutrophil chemotaxis, blocks IgE-mediated mast cell degranulation, inhibits phosphodiesterase, and blocks lymphocyte transformation. Used with tetracycline for immune-mediated skin disease.
At a glance
Class
Vitamin B3 / Immunomodulator
Storage
Store at room temperature, protect from moisture
Dosing
Used in combination with tetracycline (same dose) for discoid lupus erythematosu
Safety
Skin lesion response at 4–8 weeksHepatic enzymes with prolonged high-dose use
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Niacinamide (Nicotinamide)?
Niacinamide (Nicotinamide) is a vitamin b3 / immunomodulator used in pets. Amide form of niacin (vitamin B3) with immunomodulatory properties: inhibits neutrophil chemotaxis, blocks IgE-mediated mast cell degranulation, inhibits phosphodiesterase, and blocks lymphocyte transformation. Used with tetracycline for immune-mediated skin disease.
›What is Niacinamide (Nicotinamide) used for in pets?
Niacinamide (Nicotinamide) is used in veterinary medicine for: Used in combination with tetracycline (same dose) for discoid lupus erythematosu; Limited feline data.
›What is the Niacinamide (Nicotinamide) dose for dogs?
For dogs, Niacinamide (Nicotinamide) is typically dosed as follows — Used in combination with tetracycline (same dose) for discoid lupus erythematosu: undefined undefined PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Niacinamide (Nicotinamide) dose for cats?
For cats, Niacinamide (Nicotinamide) is typically dosed as follows — Limited feline data: undefined undefined PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Niacinamide (Nicotinamide) need a prescription?
Niacinamide (Nicotinamide) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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