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Niacinamide (Nicotinamide)

Vitamin B3 / Immunomodulator
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
2

Mechanism of action

Amide form of niacin (vitamin B3) with immunomodulatory properties: inhibits neutrophil chemotaxis, blocks IgE-mediated mast cell degranulation, inhibits phosphodiesterase, and blocks lymphocyte transformation. Used with tetracycline for immune-mediated skin disease.

At a glance

Class
Vitamin B3 / Immunomodulator
Schedule
OTC
Storage
Store at room temperature, protect from moisture

Dosing

🐕

Dog

Used in combination with tetracycline (same dose) for discoid lupus erythematosu
Dose
Route
PO
Frequency
q8h
🐈

Cat

Limited feline data
Dose
Route
PO
Frequency
q24h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature, protect from moisture

Safety

Monitoring parameters

Skin lesion response at 4–8 weeksHepatic enzymes with prolonged high-dose use
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Niacinamide supplement

FAQs

Frequently asked questions

What is Niacinamide (Nicotinamide)?
Niacinamide (Nicotinamide) is a vitamin b3 / immunomodulator used in pets. Amide form of niacin (vitamin B3) with immunomodulatory properties: inhibits neutrophil chemotaxis, blocks IgE-mediated mast cell degranulation, inhibits phosphodiesterase, and blocks lymphocyte transformation. Used with tetracycline for immune-mediated skin disease.
What is Niacinamide (Nicotinamide) used for in pets?
Niacinamide (Nicotinamide) is used in veterinary medicine for: Used in combination with tetracycline (same dose) for discoid lupus erythematosu; Limited feline data.
What is the Niacinamide (Nicotinamide) dose for dogs?
For dogs, Niacinamide (Nicotinamide) is typically dosed as follows — Used in combination with tetracycline (same dose) for discoid lupus erythematosu: undefined undefined PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Niacinamide (Nicotinamide) dose for cats?
For cats, Niacinamide (Nicotinamide) is typically dosed as follows — Limited feline data: undefined undefined PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Niacinamide (Nicotinamide) need a prescription?
Niacinamide (Nicotinamide) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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