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Miltefosine

Prescription
Alkylphosphocholine Antiprotozoal
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
2

Mechanism of action

Synthetic phospholipid analog that integrates into the parasite cell membrane, disrupting signal transduction, lipid metabolism, and membrane integrity. Also induces apoptosis-like death in Leishmania amastigotes. The only oral treatment for canine leishmaniosis.

At a glance

Class
Alkylphosphocholine Antiprotozoal
Schedule
Prescription
Storage
Store at room temperature below 30°C, protect from moisture

Dosing

🐕

Dog

Licensed in Europe for canine leishmaniosis (Leishmania infantum)
Dose
2 mg/kg
Route
PO
Frequency
q24h x 28 days
🐈

Cat

Off-label for feline leishmaniosis
Dose
2 mg/kg
Route
PO
Frequency
q24h x 28 days
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature below 30°C, protect from moisture

Safety

Monitoring parameters

Leishmania serology/PCR post-treatmentRenal function (BUN, creatinine, urinalysis)Hepatic enzymesClinical improvement (skin, lymph nodes)Body weight
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Milteforan

FAQs

Frequently asked questions

What is Miltefosine?
Miltefosine is a alkylphosphocholine antiprotozoal used in pets. Synthetic phospholipid analog that integrates into the parasite cell membrane, disrupting signal transduction, lipid metabolism, and membrane integrity. Also induces apoptosis-like death in Leishmania amastigotes. The only oral treatment for canine leishmaniosis.
What is Miltefosine used for in pets?
Miltefosine is used in veterinary medicine for: Licensed in Europe for canine leishmaniosis (Leishmania infantum); Off-label for feline leishmaniosis.
What is the Miltefosine dose for dogs?
For dogs, Miltefosine is typically dosed as follows — Licensed in Europe for canine leishmaniosis (Leishmania infantum): 2 mg/kg PO q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Miltefosine dose for cats?
For cats, Miltefosine is typically dosed as follows — Off-label for feline leishmaniosis: 2 mg/kg PO q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Miltefosine need a prescription?
Yes. Miltefosine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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