Sulfur-containing essential amino acid metabolized to sulfate, generating hydrogen ions that acidify urine. Also serves as methyl group donor for transsulfuration pathway and glutathione synthesis. Used to dissolve/prevent struvite uroliths and as hepatoprotective antioxidant.
At a glance
Class
Urinary Acidifier / Essential Amino Acid
Storage
Store at room temperature
Dosing
Used for struvite dissolution/prevention (acidifies urine to dissolve magnesium
Used for struvite prevention and acetaminophen toxicity support (with NAC)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Urine pH (target 6.0–6.5)Blood gas (acidosis)Urinalysis (crystal type)Hepatic function
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Methionine (DL-Methionine)?
Methionine (DL-Methionine) is a urinary acidifier / essential amino acid used in pets. Sulfur-containing essential amino acid metabolized to sulfate, generating hydrogen ions that acidify urine. Also serves as methyl group donor for transsulfuration pathway and glutathione synthesis. Used to dissolve/prevent struvite uroliths and as hepatoprotective antioxidant.
›What is Methionine (DL-Methionine) used for in pets?
Methionine (DL-Methionine) is used in veterinary medicine for: Used for struvite dissolution/prevention (acidifies urine to dissolve magnesium ; Used for struvite prevention and acetaminophen toxicity support (with NAC).
›What is the Methionine (DL-Methionine) dose for dogs?
For dogs, Methionine (DL-Methionine) is typically dosed as follows — Used for struvite dissolution/prevention (acidifies urine to dissolve magnesium : undefined undefined PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Methionine (DL-Methionine) dose for cats?
For cats, Methionine (DL-Methionine) is typically dosed as follows — Used for struvite prevention and acetaminophen toxicity support (with NAC): undefined undefined PO q8–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Methionine (DL-Methionine) need a prescription?
Methionine (DL-Methionine) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database