Sulfonamide-derived carbonic anhydrase inhibitor that reduces aqueous humor production in the ciliary body. Better CNS penetration and longer duration than acetazolamide. Less metabolic acidosis than dichlorphenamide.
At a glance
Class
Carbonic Anhydrase Inhibitor
Storage
Store at room temperature
Dosing
Used for glaucoma management — reduces IOP by decreasing aqueous humor productio
Same glaucoma indications
Safety
IOPSerum electrolytesBlood gasRenal function
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Methazolamide?
Methazolamide is a carbonic anhydrase inhibitor used in pets. Sulfonamide-derived carbonic anhydrase inhibitor that reduces aqueous humor production in the ciliary body. Better CNS penetration and longer duration than acetazolamide. Less metabolic acidosis than dichlorphenamide.
›What is Methazolamide used for in pets?
Methazolamide is used in veterinary medicine for: Used for glaucoma management — reduces IOP by decreasing aqueous humor productio; Same glaucoma indications.
›What is the Methazolamide dose for dogs?
For dogs, Methazolamide is typically dosed as follows — Used for glaucoma management — reduces IOP by decreasing aqueous humor productio: 2–5 mg/kg PO q8–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Methazolamide dose for cats?
For cats, Methazolamide is typically dosed as follows — Same glaucoma indications: 2–5 mg/kg PO q8–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Methazolamide need a prescription?
Yes. Methazolamide is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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