Pentavalent antimony compound (Sb5+) reduced intracellularly to trivalent form (Sb3+) within Leishmania amastigotes, which inhibits parasite ATP synthesis, fatty acid oxidation, and glycolysis, causing energy depletion and death.
At a glance
Class
Pentavalent Antimonial Antiprotozoal
Storage
Store at room temperature, protect from light
Dosing
First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S
Off-label for feline leishmaniosis
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Renal function q7 days during treatmentHepatic enzymesECGLeishmania serology/PCR post-treatmentClinical response (skin, lymph nodes, weight)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Meglumine Antimoniate?
Meglumine Antimoniate is a pentavalent antimonial antiprotozoal used in pets. Pentavalent antimony compound (Sb5+) reduced intracellularly to trivalent form (Sb3+) within Leishmania amastigotes, which inhibits parasite ATP synthesis, fatty acid oxidation, and glycolysis, causing energy depletion and death.
›What is Meglumine Antimoniate used for in pets?
Meglumine Antimoniate is used in veterinary medicine for: First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S; Off-label for feline leishmaniosis.
›What is the Meglumine Antimoniate dose for dogs?
For dogs, Meglumine Antimoniate is typically dosed as follows — First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S: 75–100 mg/kg SQ q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Meglumine Antimoniate dose for cats?
For cats, Meglumine Antimoniate is typically dosed as follows — Off-label for feline leishmaniosis: 75 mg/kg SQ q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Meglumine Antimoniate need a prescription?
Yes. Meglumine Antimoniate is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 1
Flunixin Meglumine pour on solution Finadyne Transdermal Solution
M/s Intervet India Pvt Ltd · Approved 22.11.2018
For the reduction of fever and alleviation of clinical signs of inflammation associated with bovine respiratory disease
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database