Pentavalent antimony compound (Sb5+) reduced intracellularly to trivalent form (Sb3+) within Leishmania amastigotes, which inhibits parasite ATP synthesis, fatty acid oxidation, and glycolysis, causing energy depletion and death.
At a glance
Class
Pentavalent Antimonial Antiprotozoal
Storage
Store at room temperature, protect from light
Dosing
First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S
Off-label for feline leishmaniosis
Safety
Renal function q7 days during treatmentHepatic enzymesECGLeishmania serology/PCR post-treatmentClinical response (skin, lymph nodes, weight)
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Meglumine Antimoniate?
Meglumine Antimoniate is a pentavalent antimonial antiprotozoal used in pets. Pentavalent antimony compound (Sb5+) reduced intracellularly to trivalent form (Sb3+) within Leishmania amastigotes, which inhibits parasite ATP synthesis, fatty acid oxidation, and glycolysis, causing energy depletion and death.
›What is Meglumine Antimoniate used for in pets?
Meglumine Antimoniate is used in veterinary medicine for: First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S; Off-label for feline leishmaniosis.
›What is the Meglumine Antimoniate dose for dogs?
For dogs, Meglumine Antimoniate is typically dosed as follows — First-line treatment for canine leishmaniosis in endemic areas (Mediterranean, S: 75–100 mg/kg SQ q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Meglumine Antimoniate dose for cats?
For cats, Meglumine Antimoniate is typically dosed as follows — Off-label for feline leishmaniosis: 75 mg/kg SQ q24h x 28 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Meglumine Antimoniate need a prescription?
Yes. Meglumine Antimoniate is a prescription medication and should only be administered under veterinary supervision.
References
CDSCO approvals (India) — 1
Flunixin Meglumine pour on solution Finadyne Transdermal Solution
M/s Intervet India Pvt Ltd · Approved 22.11.2018
For the reduction of fever and alleviation of clinical signs of inflammation associated with bovine respiratory disease
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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