Benzoylphenylurea compound that inhibits chitin synthesis in flea eggs and larvae, preventing proper exoskeleton formation and hatching. Does NOT kill adult fleas — breaks the flea life cycle by rendering eggs non-viable. Stored in body fat for sustained release.
At a glance
Class
Insect Development Inhibitor (Chitin Synthesis Inhibitor)
Storage
Store at room temperature below 30°C
Dosing
Flea growth regulator — prevents egg hatching, not adult kill
Program 6-month injectable (SQ) provides long-acting flea prevention for cats
Frequency
Monthly (PO); q6 months (SQ)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Flea burden assessment (environmental control needed alongside)No routine monitoring
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
Brands
United States
Sentinel (with milbemycin)
Virbac
FAQs
Frequently asked questions
›What is Lufenuron?
Lufenuron is a insect development inhibitor (chitin synthesis inhibitor) used in pets. Benzoylphenylurea compound that inhibits chitin synthesis in flea eggs and larvae, preventing proper exoskeleton formation and hatching. Does NOT kill adult fleas — breaks the flea life cycle by rendering eggs non-viable. Stored in body fat for sustained release.
›What is Lufenuron used for in pets?
Lufenuron is used in veterinary medicine for: Flea growth regulator — prevents egg hatching, not adult kill; Program 6-month injectable (SQ) provides long-acting flea prevention for cats.
›What is the Lufenuron dose for dogs?
For dogs, Lufenuron is typically dosed as follows — Flea growth regulator — prevents egg hatching, not adult kill: 10 mg/kg PO Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Lufenuron dose for cats?
For cats, Lufenuron is typically dosed as follows — Program 6-month injectable (SQ) provides long-acting flea prevention for cats: 30 mg/kg PO/SQ Monthly (PO); q6 months (SQ). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Lufenuron need a prescription?
Yes. Lufenuron is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database