L-isomer of ofloxacin with 2x greater potency. Inhibits both DNA gyrase and topoisomerase IV. Better gram-positive coverage than ciprofloxacin and ofloxacin. Good corneal and aqueous humor penetration.
At a glance
Class
Ophthalmic Third-Generation Fluoroquinolone
Storage
Store at room temperature
Dosing
Used for bacterial keratitis (1
Effective for bacterial conjunctivitis and keratitis
Safety
Clinical responseCulture and sensitivity for refractory cases
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Levofloxacin Ophthalmic?
Levofloxacin Ophthalmic is a ophthalmic third-generation fluoroquinolone used in pets. L-isomer of ofloxacin with 2x greater potency. Inhibits both DNA gyrase and topoisomerase IV. Better gram-positive coverage than ciprofloxacin and ofloxacin. Good corneal and aqueous humor penetration.
›What is Levofloxacin Ophthalmic used for in pets?
Levofloxacin Ophthalmic is used in veterinary medicine for: Used for bacterial keratitis (1; Effective for bacterial conjunctivitis and keratitis.
›What is the Levofloxacin Ophthalmic dose for dogs?
For dogs, Levofloxacin Ophthalmic is typically dosed as follows — Used for bacterial keratitis (1: undefined undefined Ophthalmic q2–6h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Levofloxacin Ophthalmic dose for cats?
For cats, Levofloxacin Ophthalmic is typically dosed as follows — Effective for bacterial conjunctivitis and keratitis: undefined undefined Ophthalmic q4–6h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Levofloxacin Ophthalmic need a prescription?
Yes. Levofloxacin Ophthalmic is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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