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L-Theanine

Amino Acid Anxiolytic / Nutraceutical
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
3

Mechanism of action

Amino acid analog from green tea that crosses the BBB and increases GABA, serotonin, and dopamine levels in the brain. Also modulates glutamate receptors and promotes alpha brainwave activity (relaxation without sedation).

At a glance

Class
Amino Acid Anxiolytic / Nutraceutical
Schedule
OTC
Storage
Store at room temperature

Dosing

🐕

Dog

Used for mild anxiety, noise phobias, and stress
Dose
Route
PO
Frequency
q12h
🐈

Cat

Used for feline anxiety, vet visit stress, and environmental changes
Dose
25–50 mg/cat
Route
PO
Frequency
q12h

Formulations

💊

Other — 3

Strength
Strength
Strength

Storage

Store at room temperature

Safety

Monitoring parameters

Behavioral responseNo routine monitoring required

Interactions

No documented interactions.

Brands

Other markets

Anxitane
Composure

FAQs

Frequently asked questions

What is L-Theanine?
L-Theanine is a amino acid anxiolytic / nutraceutical used in pets. Amino acid analog from green tea that crosses the BBB and increases GABA, serotonin, and dopamine levels in the brain. Also modulates glutamate receptors and promotes alpha brainwave activity (relaxation without sedation).
What is L-Theanine used for in pets?
L-Theanine is used in veterinary medicine for: Used for mild anxiety, noise phobias, and stress; Used for feline anxiety, vet visit stress, and environmental changes.
What is the L-Theanine dose for dogs?
For dogs, L-Theanine is typically dosed as follows — Used for mild anxiety, noise phobias, and stress: undefined undefined PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the L-Theanine dose for cats?
For cats, L-Theanine is typically dosed as follows — Used for feline anxiety, vet visit stress, and environmental changes: 25–50 mg/cat PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does L-Theanine need a prescription?
L-Theanine is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →