13-cis-retinoic acid that normalizes keratinization, reduces sebaceous gland size and sebum production (up to 90% reduction), has anti-inflammatory effects, and modulates immune function. Used for keratinization disorders in dogs.
At a glance
Class
Systemic Retinoid (Vitamin A Derivative)
Storage
Store at room temperature, protect from light and moisture
Dosing
Used for idiopathic sebaceous adenitis, sebaceous gland hyperplasia, and lamella
Safety
Schirmer tear test baseline and monthly (KCS)Hepatic enzymes q4–8 weeksTriglycerides and cholesterolPregnancy prevention
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Isotretinoin?
Isotretinoin is a systemic retinoid (vitamin a derivative) used in pets. 13-cis-retinoic acid that normalizes keratinization, reduces sebaceous gland size and sebum production (up to 90% reduction), has anti-inflammatory effects, and modulates immune function. Used for keratinization disorders in dogs.
›What is Isotretinoin used for in pets?
Isotretinoin is used in veterinary medicine for: Used for idiopathic sebaceous adenitis, sebaceous gland hyperplasia, and lamella; Very limited feline data.
›What is the Isotretinoin dose for dogs?
For dogs, Isotretinoin is typically dosed as follows — Used for idiopathic sebaceous adenitis, sebaceous gland hyperplasia, and lamella: 1–3 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Isotretinoin dose for cats?
For cats, Isotretinoin is typically dosed as follows — Very limited feline data: undefined undefined PO N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Isotretinoin need a prescription?
Yes. Isotretinoin is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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