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Irbesartan

Prescription

Angiotensin II Receptor Blocker (ARB)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

1 available

Interactions

2 documented

Formulations

Mechanism of action

Selectively blocks angiotensin II type 1 (AT1) receptors, preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and cardiac/renal remodeling. Unlike ACE inhibitors, does not cause bradykinin accumulation (no cough).

At a glance

Class

Angiotensin II Receptor Blocker (ARB)

Schedule

Prescription

Storage

Store at room temperature below 30°C

Dosing

🐕

Dog

Used for proteinuria reduction, hypertension, and as alternative or addition to

Dose

1–5 mg/kg

Route

Frequency

q24h

🐈

Cat

Off-label — telmisartan (Semintra) is the FDA-approved feline ARB and is general

Dose

1–2 mg/kg

Route

Frequency

q24h

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Store at room temperature below 30°C

Safety

Monitoring parameters

Blood pressureRenal function (BUN, creatinine)Serum potassiumUPC ratio

Educational reference only

Interactions

Major — 1

Spironolactone

major

ARB + potassium-sparing diuretic: additive potassium retention causing hyperkalemia.

Management: Monitor potassium closely. Avoid concurrent potassium supplements.

Moderate — 1

Meloxicam

moderate

NSAID opposes ARB renal protection by reducing prostaglandin-dependent afferent arteriolar vasodilation.

Management: Monitor renal function. Ensure hydration.

Educational reference only

Brands

Other markets

Avapro

FAQs

Frequently asked questions

›What is Irbesartan?

Irbesartan is a angiotensin ii receptor blocker (arb) used in pets. Selectively blocks angiotensin II type 1 (AT1) receptors, preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and cardiac/renal remodeling. Unlike ACE inhibitors, does not cause bradykinin accumulation (no cough).

›What is Irbesartan used for in pets?

Irbesartan is used in veterinary medicine for: Used for proteinuria reduction, hypertension, and as alternative or addition to ; Off-label — telmisartan (Semintra) is the FDA-approved feline ARB and is general.

›What is the Irbesartan dose for dogs?

For dogs, Irbesartan is typically dosed as follows — Used for proteinuria reduction, hypertension, and as alternative or addition to : 1–5 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Irbesartan dose for cats?

For cats, Irbesartan is typically dosed as follows — Off-label — telmisartan (Semintra) is the FDA-approved feline ARB and is general: 1–2 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Irbesartan need a prescription?

Yes. Irbesartan is a prescription medication and should only be administered under veterinary supervision.

Educational reference only