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Interferon Alfa, Human Recombinant

Prescription
Biological Response Modifier / Antiviral Cytokine
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
1

Mechanism of action

Recombinant human interferon alpha that activates JAK-STAT signaling, inducing antiviral proteins (Mx, OAS, PKR), enhancing NK cell activity, upregulating MHC class I expression, and inhibiting viral replication. Also has antiproliferative and immunomodulatory effects.

At a glance

Class
Biological Response Modifier / Antiviral Cytokine
Schedule
Prescription
Storage
Refrigerate 2–8°C; diluted oral solution frozen in aliquots stable 6 months at -20°C

Dosing

🐕

Dog

Low-dose oral (30 IU/day) for immune stimulation in papillomatosis and viral dis
Dose
1–50 IU
Route
PO (low-dose), SQ (high-dose)
Frequency
q24h
🐈

Cat

Low-dose oral IFN for feline calicivirus stomatitis, FeLV, FIV support
Dose
Route
PO, SQ
Frequency
q24h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Refrigerate 2–8°C; diluted oral solution frozen in aliquots stable 6 months at -20°C

Safety

Monitoring parameters

CBC with high-dose therapyHepatic enzymesClinical responseAntibody formation (loss of response)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Roferon-A
Intron A

FAQs

Frequently asked questions

What is Interferon Alfa, Human Recombinant?
Interferon Alfa, Human Recombinant is a biological response modifier / antiviral cytokine used in pets. Recombinant human interferon alpha that activates JAK-STAT signaling, inducing antiviral proteins (Mx, OAS, PKR), enhancing NK cell activity, upregulating MHC class I expression, and inhibiting viral replication. Also has antiproliferative and immunomodulatory effects.
What is Interferon Alfa, Human Recombinant used for in pets?
Interferon Alfa, Human Recombinant is used in veterinary medicine for: Low-dose oral (30 IU/day) for immune stimulation in papillomatosis and viral dis; Low-dose oral IFN for feline calicivirus stomatitis, FeLV, FIV support.
What is the Interferon Alfa, Human Recombinant dose for dogs?
For dogs, Interferon Alfa, Human Recombinant is typically dosed as follows — Low-dose oral (30 IU/day) for immune stimulation in papillomatosis and viral dis: 1–50 IU PO (low-dose)/SQ (high-dose) q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Interferon Alfa, Human Recombinant dose for cats?
For cats, Interferon Alfa, Human Recombinant is typically dosed as follows — Low-dose oral IFN for feline calicivirus stomatitis, FeLV, FIV support: undefined undefined PO/SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Interferon Alfa, Human Recombinant need a prescription?
Yes. Interferon Alfa, Human Recombinant is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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