Insulin analog with reversed lysine-proline sequence at B28-B29, preventing hexamer formation and enabling rapid absorption from SQ injection site. Onset 15 min, peak 30–90 min, duration 3–5h. Mimics prandial insulin release.
At a glance
Class
Rapid-Acting Insulin Analog
Storage
Refrigerate unopened 2–8°C; in-use at room temperature up to 28 days; do not freeze
Dosing
Rapid-acting analogs offer no significant advantage over regular insulin for IV
No advantage over regular insulin for IV DKA management
Safety
Blood glucose q1–2h (CRI)Serum potassiumClinical signs of hypoglycemia
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Insulin, Lispro?
Insulin, Lispro is a rapid-acting insulin analog used in pets. Insulin analog with reversed lysine-proline sequence at B28-B29, preventing hexamer formation and enabling rapid absorption from SQ injection site. Onset 15 min, peak 30–90 min, duration 3–5h. Mimics prandial insulin release.
›What is Insulin, Lispro used for in pets?
Insulin, Lispro is used in veterinary medicine for: Rapid-acting analogs offer no significant advantage over regular insulin for IV ; No advantage over regular insulin for IV DKA management.
›What is the Insulin, Lispro dose for dogs?
For dogs, Insulin, Lispro is typically dosed as follows — Rapid-acting analogs offer no significant advantage over regular insulin for IV : undefined undefined IV CRI/SQ CRI or q4–6h SQ. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Insulin, Lispro dose for cats?
For cats, Insulin, Lispro is typically dosed as follows — No advantage over regular insulin for IV DKA management: undefined undefined IV CRI/SQ CRI or q4–6h SQ. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Insulin, Lispro need a prescription?
Yes. Insulin, Lispro is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →