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Insulin, Lispro

Prescription
Rapid-Acting Insulin Analog
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
1

Mechanism of action

Insulin analog with reversed lysine-proline sequence at B28-B29, preventing hexamer formation and enabling rapid absorption from SQ injection site. Onset 15 min, peak 30–90 min, duration 3–5h. Mimics prandial insulin release.

At a glance

Class
Rapid-Acting Insulin Analog
Schedule
Prescription
Storage
Refrigerate unopened 2–8°C; in-use at room temperature up to 28 days; do not freeze

Dosing

🐕

Dog

Rapid-acting analogs offer no significant advantage over regular insulin for IV
Dose
Route
IV CRI, SQ
Frequency
CRI or q4–6h SQ
🐈

Cat

No advantage over regular insulin for IV DKA management
Dose
Route
IV CRI, SQ
Frequency
CRI or q4–6h SQ
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Refrigerate unopened 2–8°C; in-use at room temperature up to 28 days; do not freeze

Safety

Monitoring parameters

Blood glucose q1–2h (CRI)Serum potassiumClinical signs of hypoglycemia
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Humalog

FAQs

Frequently asked questions

What is Insulin, Lispro?
Insulin, Lispro is a rapid-acting insulin analog used in pets. Insulin analog with reversed lysine-proline sequence at B28-B29, preventing hexamer formation and enabling rapid absorption from SQ injection site. Onset 15 min, peak 30–90 min, duration 3–5h. Mimics prandial insulin release.
What is Insulin, Lispro used for in pets?
Insulin, Lispro is used in veterinary medicine for: Rapid-acting analogs offer no significant advantage over regular insulin for IV ; No advantage over regular insulin for IV DKA management.
What is the Insulin, Lispro dose for dogs?
For dogs, Insulin, Lispro is typically dosed as follows — Rapid-acting analogs offer no significant advantage over regular insulin for IV : undefined undefined IV CRI/SQ CRI or q4–6h SQ. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Insulin, Lispro dose for cats?
For cats, Insulin, Lispro is typically dosed as follows — No advantage over regular insulin for IV DKA management: undefined undefined IV CRI/SQ CRI or q4–6h SQ. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Insulin, Lispro need a prescription?
Yes. Insulin, Lispro is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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