Prodrug hydrolyzed to active metabolite imidaprilat which inhibits angiotensin-converting enzyme. Reduces angiotensin II and aldosterone, decreasing afterload, preload, and cardiac remodeling. Licensed for veterinary use in some countries.
At a glance
Storage
Store at room temperature below 30°C
Dosing
Licensed in Europe/Australia for CHF in dogs
Benazepril is preferred in feline CKD due to dual elimination
Safety
Blood pressureBUN/creatinineSerum potassiumClinical response
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Imidapril?
Imidapril is a ace inhibitor used in pets. Prodrug hydrolyzed to active metabolite imidaprilat which inhibits angiotensin-converting enzyme. Reduces angiotensin II and aldosterone, decreasing afterload, preload, and cardiac remodeling. Licensed for veterinary use in some countries.
›What is Imidapril used for in pets?
Imidapril is used in veterinary medicine for: Licensed in Europe/Australia for CHF in dogs; Benazepril is preferred in feline CKD due to dual elimination.
›What is the Imidapril dose for dogs?
For dogs, Imidapril is typically dosed as follows — Licensed in Europe/Australia for CHF in dogs: 0.25 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Imidapril dose for cats?
For cats, Imidapril is typically dosed as follows — Benazepril is preferred in feline CKD due to dual elimination: undefined undefined PO N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Imidapril need a prescription?
Yes. Imidapril is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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