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Grapiprant

Prescription

Piprant (EP4 prostaglandin receptor antagonist)

Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team

Species

Dog

Brands

2 available

Interactions

2 documented

Formulations

Mechanism of action

Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without inhibiting COX enzymes or other prostaglandin pathways

At a glance

Class

Piprant (EP4 prostaglandin receptor antagonist)

Schedule

Prescription

Storage

Store below 30°C

Dosing

🐕

Dog

Osteoarthritis pain and inflammation

Dose

2 mg/kg

Route

Frequency

SID

Max dose

100 mg

Duration: Long-term; administer on empty stomach or with small amount of food

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Flavored tablet — 3

Strength

20mg

Available in India

Strength

60mg

Available in India

Strength

100mg

Available in India

Storage

Store below 30°C

Safety

Absolute contraindications — do not use

Dogs < 3.6 kg or < 9 months
Cats (not approved)

Use with caution

Concurrent NSAIDs or corticosteroids
Safety not established with concurrent use

Adverse effects

Common

Vomiting

Diarrhoea

Soft stools

Inappetence

Serious

Renal or hepatic effects (rare)

Monitoring parameters

Clinical pain assessmentBody weightHepatic/renal values (periodic)

Educational reference only

Interactions

Contraindicated — 2

Carprofen

contraindicated

Both are anti-inflammatory drugs targeting prostaglandin pathways; combined use increases GI and renal toxicity risk

Management: Do not combine. Allow 24-hour washout when switching. Grapiprant is an alternative, not an adjunct, to traditional NSAIDs.

Meloxicam

contraindicated

Both target prostaglandin pathways; concurrent use increases GI ulceration and renal injury risk

Management: Never combine. Allow adequate washout period (3-5 days for meloxicam) before starting grapiprant.

Educational reference only

Brands

International

Galliprant

Elanco

India

Galliprant

Elanco India

FAQs

Frequently asked questions

›What is Grapiprant?

Grapiprant is a piprant (ep4 prostaglandin receptor antagonist) used in pets. Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without inhibiting COX enzymes or other prostaglandin pathways

›What is Grapiprant used for in pets?

Grapiprant is used in veterinary medicine for: Osteoarthritis pain and inflammation.

›What is the Grapiprant dose for dogs?

For dogs, Grapiprant is typically dosed as follows — Osteoarthritis pain and inflammation: 2 mg/kg PO SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What are the side effects of Grapiprant?

Common: Vomiting, Diarrhoea, Soft stools, Inappetence. Serious (call your vet immediately): Renal or hepatic effects (rare).

›Does Grapiprant need a prescription?

Yes. Grapiprant is a prescription medication and should only be administered under veterinary supervision.

›When should Grapiprant not be used?

Do not use Grapiprant if: Dogs < 3.6 kg or < 9 months; Cats (not approved).

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database