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Grapiprant

Prescription
Piprant (EP4 prostaglandin receptor antagonist)
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog
Brands
2 available
Interactions
2 documented
Formulations
3

Mechanism of action

Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without inhibiting COX enzymes or other prostaglandin pathways

At a glance

Class
Piprant (EP4 prostaglandin receptor antagonist)
Schedule
Prescription
Storage
Store below 30°C

Dosing

🐕

Dog

Osteoarthritis pain and inflammation
Dose
2 mg/kg
Route
PO
Frequency
SID
Max dose
100 mg
Duration: Long-term; administer on empty stomach or with small amount of food

Formulations

💊

Flavored tablet — 3

Strength
20mg
Available in India
Strength
60mg
Available in India
Strength
100mg
Available in India

Storage

Store below 30°C

Safety

Absolute contraindications — do not use

  • Dogs < 3.6 kg or < 9 months
  • Cats (not approved)

Use with caution

  • Concurrent NSAIDs or corticosteroids
    Safety not established with concurrent use

Adverse effects

Common
Vomiting
Diarrhoea
Soft stools
Inappetence
Serious
Renal or hepatic effects (rare)

Monitoring parameters

Clinical pain assessmentBody weightHepatic/renal values (periodic)

Interactions

Contraindicated — 2

Carprofen
contraindicated
Both are anti-inflammatory drugs targeting prostaglandin pathways; combined use increases GI and renal toxicity risk
Management: Do not combine. Allow 24-hour washout when switching. Grapiprant is an alternative, not an adjunct, to traditional NSAIDs.
Meloxicam
contraindicated
Both target prostaglandin pathways; concurrent use increases GI ulceration and renal injury risk
Management: Never combine. Allow adequate washout period (3-5 days for meloxicam) before starting grapiprant.

Brands

International

Galliprant
Elanco

India

Galliprant
Elanco India

FAQs

Frequently asked questions

›What is Grapiprant?
Grapiprant is a piprant (ep4 prostaglandin receptor antagonist) used in pets. Selectively blocks the EP4 prostaglandin receptor, the primary mediator of osteoarthritis pain and inflammation, without inhibiting COX enzymes or other prostaglandin pathways
›What is Grapiprant used for in pets?
Grapiprant is used in veterinary medicine for: Osteoarthritis pain and inflammation.
›What is the Grapiprant dose for dogs?
For dogs, Grapiprant is typically dosed as follows — Osteoarthritis pain and inflammation: 2 mg/kg PO SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Grapiprant?
Common: Vomiting, Diarrhoea, Soft stools, Inappetence. Serious (call your vet immediately): Renal or hepatic effects (rare).
›Does Grapiprant need a prescription?
Yes. Grapiprant is a prescription medication and should only be administered under veterinary supervision.
›When should Grapiprant not be used?
Do not use Grapiprant if: Dogs < 3.6 kg or < 9 months; Cats (not approved).

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →