Second-generation sulfonylurea that binds SUR1 subunit of KATP channels on pancreatic beta cells, closing channels and causing depolarization, which triggers insulin secretion. Requires functional beta cells. Most potent oral insulin secretagogue.
At a glance
Class
Sulfonylurea Oral Hypoglycemic
Storage
Store at room temperature below 30°C
Dosing
Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent)
Glipizide is preferred over glyburide in cats
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Blood glucose curvesFructosamineHepatic enzymesSigns of hypoglycemiaReassess need for insulin at 4–8 weeks
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Glyburide (Glibenclamide)?
Glyburide (Glibenclamide) is a sulfonylurea oral hypoglycemic used in pets. Second-generation sulfonylurea that binds SUR1 subunit of KATP channels on pancreatic beta cells, closing channels and causing depolarization, which triggers insulin secretion. Requires functional beta cells. Most potent oral insulin secretagogue.
›What is Glyburide (Glibenclamide) used for in pets?
Glyburide (Glibenclamide) is used in veterinary medicine for: Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent); Glipizide is preferred over glyburide in cats.
›What is the Glyburide (Glibenclamide) dose for dogs?
For dogs, Glyburide (Glibenclamide) is typically dosed as follows — Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent): 0.2 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Glyburide (Glibenclamide) dose for cats?
For cats, Glyburide (Glibenclamide) is typically dosed as follows — Glipizide is preferred over glyburide in cats: undefined undefined PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Glyburide (Glibenclamide) need a prescription?
Yes. Glyburide (Glibenclamide) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database