Second-generation sulfonylurea that binds SUR1 subunit of KATP channels on pancreatic beta cells, closing channels and causing depolarization, which triggers insulin secretion. Requires functional beta cells. Most potent oral insulin secretagogue.
At a glance
Class
Sulfonylurea Oral Hypoglycemic
Storage
Store at room temperature below 30°C
Dosing
Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent)
Glipizide is preferred over glyburide in cats
Safety
Blood glucose curvesFructosamineHepatic enzymesSigns of hypoglycemiaReassess need for insulin at 4–8 weeks
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Glyburide (Glibenclamide)?
Glyburide (Glibenclamide) is a sulfonylurea oral hypoglycemic used in pets. Second-generation sulfonylurea that binds SUR1 subunit of KATP channels on pancreatic beta cells, closing channels and causing depolarization, which triggers insulin secretion. Requires functional beta cells. Most potent oral insulin secretagogue.
›What is Glyburide (Glibenclamide) used for in pets?
Glyburide (Glibenclamide) is used in veterinary medicine for: Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent); Glipizide is preferred over glyburide in cats.
›What is the Glyburide (Glibenclamide) dose for dogs?
For dogs, Glyburide (Glibenclamide) is typically dosed as follows — Rarely used in dogs — canine diabetes is typically Type 1 (insulin-dependent): 0.2 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Glyburide (Glibenclamide) dose for cats?
For cats, Glyburide (Glibenclamide) is typically dosed as follows — Glipizide is preferred over glyburide in cats: undefined undefined PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Glyburide (Glibenclamide) need a prescription?
Yes. Glyburide (Glibenclamide) is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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