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Fipronil

CDSCO approved

Phenylpyrazole insecticide/acaricide

Last reviewed 18 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

3 available

Formulations

Mechanism of action

Blocks GABA-gated and glutamate-gated chloride channels in insects and ticks, causing hyperexcitation, paralysis, and death; distributed via body oils after topical application

At a glance

Class

Phenylpyrazole insecticide/acaricide

Schedule

OTC

Storage

Store below 30°C, protect from sunlight

CDSCO (India)

Vet-approved — 1990-05

Dosing

🐕

Dog

Flea and tick treatment/prevention

Dose

6.7–13.4 mg/kg

Route

Topical

Frequency

Monthly

Max dose

402 mg

Duration: Monthly year-round in endemic areas

🐈

Cat

Flea and tick treatment/prevention

Dose

6.7–13.4 mg/kg

Route

Topical

Frequency

Monthly

Max dose

100 mg

Duration: Monthly as needed

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

🧴

Spot-on solution — 3

Strength

0.67mL (small dog)

Available in India

Strength

1.34mL (medium dog)

Available in India

Strength

2.68mL (large dog)

Available in India

🧪

Spray — 1

Strength

0.25%

Available in India

Storage

Store below 30°C, protect from sunlight

Safety

Absolute contraindications — do not use

Rabbits
Fatal toxicity reported

Use with caution

Puppies/kittens under 8 weeks
Safety not fully established
Bathing within 48h of application
Reduces efficacy

Adverse effects

Common

Transient skin irritation

Hair discoloration at site

Serious

Neurological signs if ingested (rare)

Skin hypersensitivity

Monitoring parameters

Flea/tick burdenApplication site skin condition

Educational reference only

Interactions

No documented interactions.

Brands

International

Frontline

Boehringer Ingelheim

India

Fiprofort

Cipla

FiproStar

Mankind

FAQs

Frequently asked questions

›What is Fipronil?

Fipronil is a phenylpyrazole insecticide/acaricide used in pets. Blocks GABA-gated and glutamate-gated chloride channels in insects and ticks, causing hyperexcitation, paralysis, and death; distributed via body oils after topical application

›What is Fipronil used for in pets?

Fipronil is used in veterinary medicine for: Flea and tick treatment/prevention.

›What is the Fipronil dose for dogs?

For dogs, Fipronil is typically dosed as follows — Flea and tick treatment/prevention: 6.7–13.4 mg/kg Topical Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Fipronil dose for cats?

For cats, Fipronil is typically dosed as follows — Flea and tick treatment/prevention: 6.7–13.4 mg/kg Topical Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What are the side effects of Fipronil?

Common: Transient skin irritation, Hair discoloration at site. Serious (call your vet immediately): Neurological signs if ingested (rare), Skin hypersensitivity.

›Does Fipronil need a prescription?

Fipronil is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.

›When should Fipronil not be used?

Do not use Fipronil if: Rabbits.

Educational reference only

References

CDSCO approvals (India) — 9

Frontline Plus (Cats) contains: Fipronil 9.8% (S)-Methoprene 11.8% Frontline Plu

M/s. Sanofi- Synthelabo (India) Ltd. · Approved 13.04.2016

In Cats: 1. To be used against infestation with fleas, alone or in association with ticks and/or biting lice. 2 Eliminat

Fipronil 6.1 % m/v + permethrin 54.5 % m/v spot on solution for Dog Vet.

M/s Virbac Animal Healthcare Pharma India pvt ltd · Approved 20-02.2018

In dogs to be used against infestations with fleas and /or ticks when repellant anti feeding activity is necessary again

Fipronil 50mg /134mg/268/mg 402mg spot on solution for cats and dogs

M/s Virbac Animal Healthcare Pharma India pvt ltd · Approved 25-01.2018

For treatmenet of flea and ticks infestation in cats and dogs for vetrinary use only

Fipronil 8.3% w/v, (S) Methoprene 10% w/v praziquantel 8.3% w/v Eprinomection 0.

M/s Boehringer Ingelheim India Ltd · Approved 09-10.2019

This drug is recommended for cats with existing or at risk from mixed parasitic infections Treatment and prevention of i

Fipronil 0.25g/ml for external use frontline spray for cats and dogs

M/s Boehringer Ingelheim India Pvt Ltd · Approved 27.08.2021

Treatment and control of flea allergy dermatitis FAD dogs and cats. Treatment of biting lice on dogs and cats

Fipronil and Pyripproxyfen spot on solution for cats (Brant name Effipro TM Duo-

M/s Virbac Animal Health India pvt ltd · Approved 16.03.2022

In cats, to be used against infestations with flea alone or in association with ticks. one week. If ticks are present at

Fipronil and Pyriproxyfen spot on solution for dogs

M/s Virbac Animal Health India pvt ltd · Approved 06.05.2022

to be used against infestations with flea alone or in asociation with ticks. Against fleas: a) treatment and prevention

Fipronil Tablets 5mg 10mg, and 20 mg tablets for Veterinry use only)

M/s International Health Care Limited, · Approved 07.11.2022

Solid oral dosage from as tablet Compressed form for vet use

Fipronil Oral Bolus 150 mg for (Veterinary use only)

M/s International Health Care Limited, · Approved 16.08.2023

For the control of endo and Ecto-Parasites very effective to kill files like Stomoxys calcitrans, Hydrotea irritans taba

Source: CDSCO Veterinary Drug Approval Registry (1969–2026)

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database