Synthetic exendin-4 (Gila monster venom peptide) that activates GLP-1 receptors on pancreatic beta cells, enhancing glucose-dependent insulin secretion, suppressing glucagon, slowing gastric emptying, and promoting satiety. Only stimulates insulin when glucose is elevated.
At a glance
Class
GLP-1 Receptor Agonist (Incretin Mimetic)
Storage
Refrigerate 2–8°C; pen in use can be at room temperature up to 30 days
Dosing
Off-label investigational use for canine diabetes and insulinoma (paradoxically
Investigational for feline diabetes — may promote beta cell regeneration and dia
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Blood glucose curvesFructosamineBody weightGI toleranceLipase (pancreatitis screening)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Exenatide?
Exenatide is a glp-1 receptor agonist (incretin mimetic) used in pets. Synthetic exendin-4 (Gila monster venom peptide) that activates GLP-1 receptors on pancreatic beta cells, enhancing glucose-dependent insulin secretion, suppressing glucagon, slowing gastric emptying, and promoting satiety. Only stimulates insulin when glucose is elevated.
›What is Exenatide used for in pets?
Exenatide is used in veterinary medicine for: Off-label investigational use for canine diabetes and insulinoma (paradoxically ; Investigational for feline diabetes — may promote beta cell regeneration and dia.
›What is the Exenatide dose for dogs?
For dogs, Exenatide is typically dosed as follows — Off-label investigational use for canine diabetes and insulinoma (paradoxically : 0.2–1 mcg/kg SQ q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Exenatide dose for cats?
For cats, Exenatide is typically dosed as follows — Investigational for feline diabetes — may promote beta cell regeneration and dia: 0.2 mcg/kg SQ q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Exenatide need a prescription?
Yes. Exenatide is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database