Weak, short-acting natural estrogen that binds estrogen receptors in urethral mucosa and sphincter, increasing urethral closure pressure and sensitizing alpha-adrenergic receptors. Much shorter-acting and safer than DES or estradiol — no bone marrow suppression.
At a glance
Class
Short-Acting Estrogen
Storage
Store at room temperature below 25°C
Dosing
FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe
Feline urinary incontinence from USMI is rare
Safety
Incontinence resolutionVulvar swelling (dose too high)CBC annually (though bone marrow toxicity not expected)
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Estriol?
Estriol is a short-acting estrogen used in pets. Weak, short-acting natural estrogen that binds estrogen receptors in urethral mucosa and sphincter, increasing urethral closure pressure and sensitizing alpha-adrenergic receptors. Much shorter-acting and safer than DES or estradiol — no bone marrow suppression.
›What is Estriol used for in pets?
Estriol is used in veterinary medicine for: FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe; Feline urinary incontinence from USMI is rare.
›What is the Estriol dose for dogs?
For dogs, Estriol is typically dosed as follows — FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe: 1–2 mg/dog PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Estriol dose for cats?
For cats, Estriol is typically dosed as follows — Feline urinary incontinence from USMI is rare: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Estriol need a prescription?
Yes. Estriol is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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