Weak, short-acting natural estrogen that binds estrogen receptors in urethral mucosa and sphincter, increasing urethral closure pressure and sensitizing alpha-adrenergic receptors. Much shorter-acting and safer than DES or estradiol — no bone marrow suppression.
At a glance
Class
Short-Acting Estrogen
Storage
Store at room temperature below 25°C
Dosing
FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe
Feline urinary incontinence from USMI is rare
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Incontinence resolutionVulvar swelling (dose too high)CBC annually (though bone marrow toxicity not expected)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Estriol?
Estriol is a short-acting estrogen used in pets. Weak, short-acting natural estrogen that binds estrogen receptors in urethral mucosa and sphincter, increasing urethral closure pressure and sensitizing alpha-adrenergic receptors. Much shorter-acting and safer than DES or estradiol — no bone marrow suppression.
›What is Estriol used for in pets?
Estriol is used in veterinary medicine for: FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe; Feline urinary incontinence from USMI is rare.
›What is the Estriol dose for dogs?
For dogs, Estriol is typically dosed as follows — FDA-approved (Incurin) for estrogen-responsive urinary incontinence in spayed fe: 1–2 mg/dog PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Estriol dose for cats?
For cats, Estriol is typically dosed as follows — Feline urinary incontinence from USMI is rare: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Estriol need a prescription?
Yes. Estriol is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database