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Estradiol

Prescription

Estrogen Hormone

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

3 available

Interactions

1 documented

Formulations

Mechanism of action

Synthetic or natural estrogen that binds to estrogen receptors (ERα and ERβ), regulating gene transcription involved in female reproductive function, bone density, cardiovascular function, and secondary sex characteristics.

At a glance

Class

Estrogen Hormone

Schedule

Prescription

Storage

Store at room temperature, protect from light

Dosing

🐕

Dog

Mismating injection (ECP) is controversial and potentially dangerous (fatal apla

Dose

—

Route

Frequency

Once

🐈

Cat

Extreme caution in cats — profound bone marrow suppression and pyometra risk

Dose

—

Route

Frequency

Per specific protocol

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 3

Strength

—

Strength

—

Strength

—

Storage

Store at room temperature, protect from light

Safety

Monitoring parameters

CBC (weekly for 4 weeks after injection — watch for aplastic anemia)Vaginal cytologyUterine ultrasound

Educational reference only

Interactions

Major — 1

Tranexamic Acid

major

Estrogens increase clotting factor synthesis and reduce antithrombin III. Tranexamic acid inhibits fibrinolysis. Combined: significantly increased thromboembolism risk.

Management: Avoid combination. If antifibrinolytic needed in patient on estrogen, monitor closely for thrombosis.

Educational reference only

Brands

Other markets

ECP (Estradiol Cypionate)

Premarin (estrogens)

Estrace

FAQs

Frequently asked questions

›What is Estradiol?

Estradiol is a estrogen hormone used in pets. Synthetic or natural estrogen that binds to estrogen receptors (ERα and ERβ), regulating gene transcription involved in female reproductive function, bone density, cardiovascular function, and secondary sex characteristics.

›What is Estradiol used for in pets?

Estradiol is used in veterinary medicine for: Mismating injection (ECP) is controversial and potentially dangerous (fatal apla; Extreme caution in cats — profound bone marrow suppression and pyometra risk.

›What is the Estradiol dose for dogs?

For dogs, Estradiol is typically dosed as follows — Mismating injection (ECP) is controversial and potentially dangerous (fatal apla: undefined undefined IM Once. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Estradiol dose for cats?

For cats, Estradiol is typically dosed as follows — Extreme caution in cats — profound bone marrow suppression and pyometra risk: undefined undefined IM Per specific protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Estradiol need a prescription?

Yes. Estradiol is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database