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Erythropoietin (Epoetin Alfa)

Prescription
Recombinant Erythropoiesis-Stimulating Agent (ESA)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
1

Mechanism of action

Recombinant human erythropoietin that stimulates proliferation and differentiation of erythroid progenitor cells in bone marrow, increasing red blood cell production. Used for anemia of chronic kidney disease.

At a glance

Class
Recombinant Erythropoiesis-Stimulating Agent (ESA)
Schedule
Prescription
Storage
Refrigerate 2–8°C; do not freeze or shake; discard unused portion of single-dose vials

Dosing

🐕

Dog

Used for anemia of CKD
Dose
100 units/kg
Route
SQ
Frequency
3x/week (then taper to weekly)
🐈

Cat

Anti-EPO antibody formation more problematic in cats (30–50% develop profound an
Dose
100 units/kg
Route
SQ
Frequency
3x/week (taper to weekly)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Refrigerate 2–8°C; do not freeze or shake; discard unused portion of single-dose vials

Safety

Monitoring parameters

PCV/hematocrit every 2 weeks until stable, then monthlyBlood pressureSerum iron, transferrin saturationReticulocyte count
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Epogen
Procrit
Eprex

FAQs

Frequently asked questions

What is Erythropoietin (Epoetin Alfa)?
Erythropoietin (Epoetin Alfa) is a recombinant erythropoiesis-stimulating agent (esa) used in pets. Recombinant human erythropoietin that stimulates proliferation and differentiation of erythroid progenitor cells in bone marrow, increasing red blood cell production. Used for anemia of chronic kidney disease.
What is Erythropoietin (Epoetin Alfa) used for in pets?
Erythropoietin (Epoetin Alfa) is used in veterinary medicine for: Used for anemia of CKD; Anti-EPO antibody formation more problematic in cats (30–50% develop profound an.
What is the Erythropoietin (Epoetin Alfa) dose for dogs?
For dogs, Erythropoietin (Epoetin Alfa) is typically dosed as follows — Used for anemia of CKD: 100 units/kg SQ 3x/week (then taper to weekly). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Erythropoietin (Epoetin Alfa) dose for cats?
For cats, Erythropoietin (Epoetin Alfa) is typically dosed as follows — Anti-EPO antibody formation more problematic in cats (30–50% develop profound an: 100 units/kg SQ 3x/week (taper to weekly). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Erythropoietin (Epoetin Alfa) need a prescription?
Yes. Erythropoietin (Epoetin Alfa) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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