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Enoxaparin

Prescription

Low-Molecular-Weight Heparin (LMWH)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

2 available

Interactions

3 documented

Formulations

Mechanism of action

Selectively inhibits Factor Xa via antithrombin III binding. More predictable pharmacokinetics and longer half-life than unfractionated heparin.

At a glance

Class

Low-Molecular-Weight Heparin (LMWH)

Schedule

Prescription

Storage

Store at room temperature below 25°C; do not freeze

Dosing

🐕

Dog

Used for thromboembolic disease

Dose

—

Route

Frequency

q6h

🐈

Cat

Used for feline ATE prevention and treatment

Dose

1 mg/kg

Route

Frequency

q6–12h

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Store at room temperature below 25°C; do not freeze

Safety

Monitoring parameters

Anti-Xa levelsPCV/TSPlatelet countBleeding signs

Educational reference only

Interactions

Major — 2

Meloxicam

major

NSAID platelet dysfunction + LMWH anticoagulation: significantly increased bleeding risk.

Management: Avoid if possible. If both needed, monitor for bleeding (petechiae, melena, hematuria). Use gastroprotectant.

Aspirin (Acetylsalicylic Acid)

major

Aspirin irreversibly inhibits platelet COX-1 (TXA2) + LMWH inhibits Factor Xa: marked additive bleeding risk.

Management: Extreme caution. Only combine under specialist guidance for specific thrombotic conditions (e.g., post-ATE in cats). Monitor bleeding closely.

Moderate — 1

Protamine Sulfate

moderate

Protamine only partially reverses LMWH (~60% of anti-Xa activity neutralized, vs 100% for unfractionated heparin). Incomplete reversal.

Management: Give protamine 1 mg per 100 anti-Xa units of enoxaparin. Expect only partial reversal. May need repeat dosing. Monitor anti-Xa activity.

Educational reference only

Brands

Other markets

Lovenox

Clexane

FAQs

Frequently asked questions

›What is Enoxaparin?

Enoxaparin is a low-molecular-weight heparin (lmwh) used in pets. Selectively inhibits Factor Xa via antithrombin III binding. More predictable pharmacokinetics and longer half-life than unfractionated heparin.

›What is Enoxaparin used for in pets?

Enoxaparin is used in veterinary medicine for: Used for thromboembolic disease; Used for feline ATE prevention and treatment.

›What is the Enoxaparin dose for dogs?

For dogs, Enoxaparin is typically dosed as follows — Used for thromboembolic disease: undefined undefined SQ q6h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Enoxaparin dose for cats?

For cats, Enoxaparin is typically dosed as follows — Used for feline ATE prevention and treatment: 1 mg/kg SQ q6–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Enoxaparin need a prescription?

Yes. Enoxaparin is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Low-Molecular-Weight Heparin).

Dalteparin

Binds antithrombin III and selectively inhibits Factor Xa, preventing thrombin generation. More predictable pharmacokinetics and longer half-life than unfractionated heparin.

dogcat