Emodepside activates presynaptic latrophilin receptors and SLO-1 potassium channels in nematodes, causing paralysis. Praziquantel disrupts calcium homeostasis in cestode tegument causing paralysis and disintegration. Together cover both roundworms and tapeworms.
At a glance
Class
Topical Anthelmintic Combination
Storage
Store at room temperature below 30°C
Dosing
Profender is formulated for cats only
FDA-approved for cats for roundworms (Toxocara cati, Ancylostoma tubaeforme) and
Frequency
Once; repeat as needed for re-infection
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Fecal exam 2–4 weeks post-treatmentApplication site for irritation
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Emodepside/Praziquantel?
Emodepside/Praziquantel is a topical anthelmintic combination used in pets. Emodepside activates presynaptic latrophilin receptors and SLO-1 potassium channels in nematodes, causing paralysis. Praziquantel disrupts calcium homeostasis in cestode tegument causing paralysis and disintegration. Together cover both roundworms and tapeworms.
›What is Emodepside/Praziquantel used for in pets?
Emodepside/Praziquantel is used in veterinary medicine for: Profender is formulated for cats only; FDA-approved for cats for roundworms (Toxocara cati, Ancylostoma tubaeforme) and.
›What is the Emodepside/Praziquantel dose for dogs?
For dogs, Emodepside/Praziquantel is typically dosed as follows — Profender is formulated for cats only: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Emodepside/Praziquantel dose for cats?
For cats, Emodepside/Praziquantel is typically dosed as follows — FDA-approved for cats for roundworms (Toxocara cati, Ancylostoma tubaeforme) and: undefined undefined Topical (spot-on) Once; repeat as needed for re-infection. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Emodepside/Praziquantel need a prescription?
Yes. Emodepside/Praziquantel is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database