Natural prostaglandin F2α that causes luteolysis (corpus luteum regression) by decreasing progesterone production, smooth muscle contraction of the uterus and GI tract, and bronchoconstriction. Used for estrus induction and pyometra treatment.
At a glance
Class
Prostaglandin F2α (PGF2α)
Storage
Store at 2–25°C, protect from light
Dosing
Low-dose protocol preferred to minimize side effects
Frequency
q12–24h (pyometra) or once (luteolysis)
Cats are more sensitive to PGF2α side effects — vocalization, salivation, and GI
Safety
Vaginal discharge characterSerial ultrasound to monitor uterine sizeCBC and biochemistry (systemic response in pyometra)Temperature
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Dinoprost?
Dinoprost is a prostaglandin f2α (pgf2α) used in pets. Natural prostaglandin F2α that causes luteolysis (corpus luteum regression) by decreasing progesterone production, smooth muscle contraction of the uterus and GI tract, and bronchoconstriction. Used for estrus induction and pyometra treatment.
›What is Dinoprost used for in pets?
Dinoprost is used in veterinary medicine for: Low-dose protocol preferred to minimize side effects; Cats are more sensitive to PGF2α side effects — vocalization, salivation, and GI.
›What is the Dinoprost dose for dogs?
For dogs, Dinoprost is typically dosed as follows — Low-dose protocol preferred to minimize side effects: 25–100 mcg/kg SQ q12–24h (pyometra) or once (luteolysis). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Dinoprost dose for cats?
For cats, Dinoprost is typically dosed as follows — Cats are more sensitive to PGF2α side effects — vocalization, salivation, and GI: 100 mcg/kg SQ q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Dinoprost need a prescription?
Yes. Dinoprost is a prescription medication and should only be administered under veterinary supervision.
References
CDSCO approvals (India) — 1
SND Dinoprost Tromethamine Injection 12.5 mg/ml
M/s Zoetis India Limited, 31, 3rd Floor, Kalpataru Synergy, · Approved 12.03.2026
1. For estrus synchronization in beef cows, beef heifers and replacement dairy heifers. 2. For unobserved (silent) estru
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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