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Dicloxacillin

Prescription
Penicillinase-Resistant Penicillin
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
2

Mechanism of action

Isoxazolyl penicillin resistant to staphylococcal beta-lactamase (penicillinase). Inhibits bacterial cell wall synthesis by binding PBPs. Narrow spectrum — primarily methicillin-susceptible Staphylococcus aureus (MSSA) and streptococci.

At a glance

Class
Penicillinase-Resistant Penicillin
Schedule
Prescription
Storage
Store at room temperature; oral solution refrigerated after reconstitution

Dosing

🐕

Dog

Used for staphylococcal skin infections, osteomyelitis, and wound infections whe
Dose
11–25 mg/kg
Route
PO
Frequency
q8h
🐈

Cat

Same indications as dogs
Dose
11–25 mg/kg
Route
PO
Frequency
q8h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature; oral solution refrigerated after reconstitution

Safety

Monitoring parameters

Clinical responseCulture and sensitivityHepatic enzymes with prolonged use
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Dynapen
Pathocil

FAQs

Frequently asked questions

What is Dicloxacillin?
Dicloxacillin is a penicillinase-resistant penicillin used in pets. Isoxazolyl penicillin resistant to staphylococcal beta-lactamase (penicillinase). Inhibits bacterial cell wall synthesis by binding PBPs. Narrow spectrum — primarily methicillin-susceptible Staphylococcus aureus (MSSA) and streptococci.
What is Dicloxacillin used for in pets?
Dicloxacillin is used in veterinary medicine for: Used for staphylococcal skin infections, osteomyelitis, and wound infections whe; Same indications as dogs.
What is the Dicloxacillin dose for dogs?
For dogs, Dicloxacillin is typically dosed as follows — Used for staphylococcal skin infections, osteomyelitis, and wound infections whe: 11–25 mg/kg PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Dicloxacillin dose for cats?
For cats, Dicloxacillin is typically dosed as follows — Same indications as dogs: 11–25 mg/kg PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Dicloxacillin need a prescription?
Yes. Dicloxacillin is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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