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Dextrose 50%

Prescription
Hypertonic glucose solution
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
1

Mechanism of action

Provides immediate glucose for cellular energy; raises blood glucose in hypoglycemia; osmotic effect draws potassium intracellularly (when combined with insulin) for hyperkalemia management

At a glance

Class
Hypertonic glucose solution
Schedule
Prescription
Storage
Below 25°C, protect from light

Dosing

🐕

Dog

Hypoglycemia, hyperkalemia (with insulin), hepatic encephalopathy support
Dose
0.5–1 mL/kg
Route
IV (dilute to 25% or less)
Frequency
To effect; then CRI 2.5–5% dextrose in fluids
Max dose
50 mL/dose; 0 mL/day
Duration: Until euglycemia maintained
🐈

Cat

Hypoglycemia, hyperkalemia
Dose
0.5–1 mL/kg
Route
IV (dilute to 25% or less)
Frequency
To effect; then CRI 2.5–5% dextrose in fluids
Max dose
10 mL/dose; 0 mL/day
Duration: Until euglycemia maintained
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💉

Injectable solution — 1

Strength
50% (500mg/mL)
Available in India

Storage

Below 25°C, protect from light

Safety

Absolute contraindications — do not use

  • Hyperglycemia / uncontrolled diabetes

Use with caution

  • Dehydration
    Hypertonic solution may worsen dehydration; correct fluid deficit first

Adverse effects

Common
Hyperglycemia
Phlebitis at injection site
Serious
Osmotic diuresis
Cerebral edema (neonates)
Tissue necrosis if perivascular

Monitoring parameters

Blood glucose (every 1–2 hours initially)Serum electrolytesInjection site for phlebitis
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

International

Dextrose 50% Injection
Various

India

DNS/Dextrose
Claris Lifesciences
Dextrose 50%
Baxter India

FAQs

Frequently asked questions

What is Dextrose 50%?
Dextrose 50% is a hypertonic glucose solution used in pets. Provides immediate glucose for cellular energy; raises blood glucose in hypoglycemia; osmotic effect draws potassium intracellularly (when combined with insulin) for hyperkalemia management
What is Dextrose 50% used for in pets?
Dextrose 50% is used in veterinary medicine for: Hypoglycemia, hyperkalemia (with insulin), hepatic encephalopathy support; Hypoglycemia, hyperkalemia.
What is the Dextrose 50% dose for dogs?
For dogs, Dextrose 50% is typically dosed as follows — Hypoglycemia, hyperkalemia (with insulin), hepatic encephalopathy support: 0.5–1 mL/kg IV (dilute to 25% or less) To effect; then CRI 2.5–5% dextrose in fluids. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Dextrose 50% dose for cats?
For cats, Dextrose 50% is typically dosed as follows — Hypoglycemia, hyperkalemia: 0.5–1 mL/kg IV (dilute to 25% or less) To effect; then CRI 2.5–5% dextrose in fluids. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What are the side effects of Dextrose 50%?
Common: Hyperglycemia, Phlebitis at injection site. Serious (call your vet immediately): Osmotic diuresis, Cerebral edema (neonates), Tissue necrosis if perivascular.
Does Dextrose 50% need a prescription?
Yes. Dextrose 50% is a prescription medication and should only be administered under veterinary supervision.
When should Dextrose 50% not be used?
Do not use Dextrose 50% if: Hyperglycemia / uncontrolled diabetes.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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