Intracellularly converted to an iron chelator that prevents iron-catalyzed free radical generation responsible for anthracycline cardiotoxicity. Does not reduce antitumor efficacy.
At a glance
Class
Cardioprotective Agent / Iron Chelator
Storage
Store at room temperature; reconstituted use within 1h; diluted within 6h
Dosing
Allows higher cumulative doxorubicin doses by protecting against cardiotoxicity
Frequency
With each doxorubicin treatment
Limited feline data but same rationale
Frequency
With each doxorubicin dose
Safety
CBCEchocardiogram (continued monitoring)Tumor response
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Dexrazoxane?
Dexrazoxane is a cardioprotective agent / iron chelator used in pets. Intracellularly converted to an iron chelator that prevents iron-catalyzed free radical generation responsible for anthracycline cardiotoxicity. Does not reduce antitumor efficacy.
›What is Dexrazoxane used for in pets?
Dexrazoxane is used in veterinary medicine for: Allows higher cumulative doxorubicin doses by protecting against cardiotoxicity; Limited feline data but same rationale.
›What is the Dexrazoxane dose for dogs?
For dogs, Dexrazoxane is typically dosed as follows — Allows higher cumulative doxorubicin doses by protecting against cardiotoxicity: undefined undefined PO With each doxorubicin treatment. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Dexrazoxane dose for cats?
For cats, Dexrazoxane is typically dosed as follows — Limited feline data but same rationale: undefined undefined IV With each doxorubicin dose. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Dexrazoxane need a prescription?
Yes. Dexrazoxane is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →