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Detomidine

Prescription
Alpha-2 Adrenergic Agonist / Sedative
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Interactions
1 documented
Formulations
1

Mechanism of action

Potent and selective alpha-2 adrenergic receptor agonist (similar to medetomidine) that inhibits norepinephrine release, producing profound sedation, analgesia, and muscle relaxation. Primarily licensed for equine use but used off-label in small animals.

At a glance

Class
Alpha-2 Adrenergic Agonist / Sedative
Schedule
Prescription
Storage
Store at room temperature, protect from light

Dosing

🐕

Dog

Off-label in dogs — medetomidine/dexmedetomidine preferred
Dose
10–40 mcg/kg
Route
IM, IV
Frequency
Single sedation dose
🐈

Cat

Off-label in cats
Dose
20–40 mcg/kg
Route
IM
Frequency
Single dose

Formulations

💊

Other — 1

Strength
—

Storage

Store at room temperature, protect from light

Safety

Monitoring parameters

Heart rate and ECGBlood pressureSpO2Body temperatureLevel of sedation

Interactions

Moderate — 1

Ketamine
moderate
Same pharmacological combination as dexmedetomidine/medetomidine + ketamine. Synergistic sedation.
Management: Standard combination (primarily equine but used off-label in small animals). Monitor cardiovascular parameters.

Brands

Other markets

Dormosedan

FAQs

Frequently asked questions

›What is Detomidine?
Detomidine is a alpha-2 adrenergic agonist / sedative used in pets. Potent and selective alpha-2 adrenergic receptor agonist (similar to medetomidine) that inhibits norepinephrine release, producing profound sedation, analgesia, and muscle relaxation. Primarily licensed for equine use but used off-label in small animals.
›What is Detomidine used for in pets?
Detomidine is used in veterinary medicine for: Off-label in dogs — medetomidine/dexmedetomidine preferred; Off-label in cats.
›What is the Detomidine dose for dogs?
For dogs, Detomidine is typically dosed as follows — Off-label in dogs — medetomidine/dexmedetomidine preferred: 10–40 mcg/kg IM/IV Single sedation dose. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Detomidine dose for cats?
For cats, Detomidine is typically dosed as follows — Off-label in cats: 20–40 mcg/kg IM Single dose. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Detomidine need a prescription?
Yes. Detomidine is a prescription medication and should only be administered under veterinary supervision.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →