Purified proanthocyanidin extracted from Croton lechleri (dragon's blood tree) that inhibits both CFTR chloride channels and calcium-activated chloride channels (CaCC) in intestinal epithelium, reducing chloride and water secretion into the gut lumen without affecting motility.
At a glance
Class
Antisecretory Antidiarrheal (Botanical)
Storage
Store at room temperature below 30°C
Dosing
FDA-approved for chemotherapy-induced diarrhea in dogs
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Stool consistency and frequencyClinical response within 48h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Crofelemer?
Crofelemer is a antisecretory antidiarrheal (botanical) used in pets. Purified proanthocyanidin extracted from Croton lechleri (dragon's blood tree) that inhibits both CFTR chloride channels and calcium-activated chloride channels (CaCC) in intestinal epithelium, reducing chloride and water secretion into the gut lumen without affecting motility.
›What is Crofelemer used for in pets?
Crofelemer is used in veterinary medicine for: FDA-approved for chemotherapy-induced diarrhea in dogs; Limited feline data.
›What is the Crofelemer dose for dogs?
For dogs, Crofelemer is typically dosed as follows — FDA-approved for chemotherapy-induced diarrhea in dogs: 1 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Crofelemer dose for cats?
For cats, Crofelemer is typically dosed as follows — Limited feline data: undefined undefined PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Crofelemer need a prescription?
Yes. Crofelemer is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database