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Corticotropin (ACTH)

Prescription
Adrenocorticotropic Hormone
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
1

Mechanism of action

Natural ACTH (39 amino acids) that stimulates adrenal cortex to produce cortisol, corticosterone, and aldosterone. Repository gel formulation provides sustained ACTH release. Used diagnostically (ACTH stimulation test) and therapeutically.

At a glance

Class
Adrenocorticotropic Hormone
Schedule
Prescription
Storage
Refrigerate 2–8°C; do not freeze

Dosing

🐕

Dog

ACTH gel largely replaced by cosyntropin for diagnostic testing (more standardiz
Dose
Route
IM
Frequency
Once (diagnostic); q24–48h (therapeutic)
🐈

Cat

Cosyntropin strongly preferred over ACTH gel for diagnostic testing in cats
Dose
2.2 IU/kg
Route
IM
Frequency
Once (diagnostic)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Refrigerate 2–8°C; do not freeze

Safety

Monitoring parameters

Pre and post cortisol levels (diagnostic)ElectrolytesBlood glucose
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Acthar Gel
H.P. Acthar

FAQs

Frequently asked questions

What is Corticotropin (ACTH)?
Corticotropin (ACTH) is a adrenocorticotropic hormone used in pets. Natural ACTH (39 amino acids) that stimulates adrenal cortex to produce cortisol, corticosterone, and aldosterone. Repository gel formulation provides sustained ACTH release. Used diagnostically (ACTH stimulation test) and therapeutically.
What is Corticotropin (ACTH) used for in pets?
Corticotropin (ACTH) is used in veterinary medicine for: ACTH gel largely replaced by cosyntropin for diagnostic testing (more standardiz; Cosyntropin strongly preferred over ACTH gel for diagnostic testing in cats.
What is the Corticotropin (ACTH) dose for dogs?
For dogs, Corticotropin (ACTH) is typically dosed as follows — ACTH gel largely replaced by cosyntropin for diagnostic testing (more standardiz: undefined undefined IM Once (diagnostic); q24–48h (therapeutic). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Corticotropin (ACTH) dose for cats?
For cats, Corticotropin (ACTH) is typically dosed as follows — Cosyntropin strongly preferred over ACTH gel for diagnostic testing in cats: 2.2 IU/kg IM Once (diagnostic). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Corticotropin (ACTH) need a prescription?
Yes. Corticotropin (ACTH) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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