Synthetic analog of PGF2α with higher specificity for the FP prostaglandin receptor and fewer side effects than natural PGF2α. Causes luteolysis, uterine contractions, and cervical relaxation.
At a glance
Class
Synthetic Prostaglandin F2α Analog
Storage
Store at room temperature; protect from light; stable 48h after drawing into syringe
Dosing
More potent than dinoprost; use lower doses accordingly
More tolerated than dinoprost at equivalent therapeutic effect
Safety
Uterine size on ultrasoundVaginal discharge characterClinical responseCBC in pyometra patients
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Cloprostenol?
Cloprostenol is a synthetic prostaglandin f2α analog used in pets. Synthetic analog of PGF2α with higher specificity for the FP prostaglandin receptor and fewer side effects than natural PGF2α. Causes luteolysis, uterine contractions, and cervical relaxation.
›What is Cloprostenol used for in pets?
Cloprostenol is used in veterinary medicine for: More potent than dinoprost; use lower doses accordingly; More tolerated than dinoprost at equivalent therapeutic effect.
›What is the Cloprostenol dose for dogs?
For dogs, Cloprostenol is typically dosed as follows — More potent than dinoprost; use lower doses accordingly: 1–5 mcg/kg SQ q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Cloprostenol dose for cats?
For cats, Cloprostenol is typically dosed as follows — More tolerated than dinoprost at equivalent therapeutic effect: 1–2.5 mcg/kg SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Cloprostenol need a prescription?
Yes. Cloprostenol is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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