Synthetic analog of PGF2α with higher specificity for the FP prostaglandin receptor and fewer side effects than natural PGF2α. Causes luteolysis, uterine contractions, and cervical relaxation.
At a glance
Class
Synthetic Prostaglandin F2α Analog
Storage
Store at room temperature; protect from light; stable 48h after drawing into syringe
Dosing
More potent than dinoprost; use lower doses accordingly
More tolerated than dinoprost at equivalent therapeutic effect
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Uterine size on ultrasoundVaginal discharge characterClinical responseCBC in pyometra patients
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Cloprostenol?
Cloprostenol is a synthetic prostaglandin f2α analog used in pets. Synthetic analog of PGF2α with higher specificity for the FP prostaglandin receptor and fewer side effects than natural PGF2α. Causes luteolysis, uterine contractions, and cervical relaxation.
›What is Cloprostenol used for in pets?
Cloprostenol is used in veterinary medicine for: More potent than dinoprost; use lower doses accordingly; More tolerated than dinoprost at equivalent therapeutic effect.
›What is the Cloprostenol dose for dogs?
For dogs, Cloprostenol is typically dosed as follows — More potent than dinoprost; use lower doses accordingly: 1–5 mcg/kg SQ q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Cloprostenol dose for cats?
For cats, Cloprostenol is typically dosed as follows — More tolerated than dinoprost at equivalent therapeutic effect: 1–2.5 mcg/kg SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Cloprostenol need a prescription?
Yes. Cloprostenol is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database