Binds to mycobacterial DNA and inhibits template function, blocking replication. Also generates reactive oxygen species within macrophages and has anti-inflammatory/immunomodulatory properties. Extremely lipophilic with tissue accumulation.
At a glance
Class
Antimycobacterial / Riminophenazine
Storage
Store at room temperature, protect from moisture
Dosing
Used for mycobacterial infections (M
Used for feline leprosy and other mycobacterial infections
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Hepatic enzymes q3 monthsGI toleranceClinical/culture responseSkin changes (expected)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Clofazimine?
Clofazimine is a antimycobacterial / riminophenazine used in pets. Binds to mycobacterial DNA and inhibits template function, blocking replication. Also generates reactive oxygen species within macrophages and has anti-inflammatory/immunomodulatory properties. Extremely lipophilic with tissue accumulation.
›What is Clofazimine used for in pets?
Clofazimine is used in veterinary medicine for: Used for mycobacterial infections (M; Used for feline leprosy and other mycobacterial infections.
›What is the Clofazimine dose for dogs?
For dogs, Clofazimine is typically dosed as follows — Used for mycobacterial infections (M: 1–4 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Clofazimine dose for cats?
For cats, Clofazimine is typically dosed as follows — Used for feline leprosy and other mycobacterial infections: 8–25 mg/cat PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Clofazimine need a prescription?
Yes. Clofazimine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database