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Chlorothiazide

Prescription

Thiazide Diuretic

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

1 available

Interactions

1 documented

Formulations

Mechanism of action

Inhibits Na+/Cl- cotransporter in the distal convoluted tubule, reducing sodium and chloride reabsorption and promoting diuresis. Also causes mild vasodilation and reduces renal calcium excretion (useful in hypercalciuria).

At a glance

Class

Thiazide Diuretic

Schedule

Prescription

Storage

Store at room temperature; oral suspension refrigerated after reconstitution

Dosing

🐕

Dog

Used for edema, mild CHF (adjunct to furosemide for diuretic resistance — sequen

Dose

20–40 mg/kg

Route

PO, IV

Frequency

q12h

🐈

Cat

Used adjunctively with furosemide for diuretic resistance and for calcium oxalat

Dose

10–20 mg/kg

Route

Frequency

q12h

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 3

Strength

—

Strength

—

Strength

—

Storage

Store at room temperature; oral suspension refrigerated after reconstitution

Safety

Monitoring parameters

Serum electrolytes (K, Na, Cl, Ca)BUN/creatinineBlood glucoseBody weightBlood pressure

Educational reference only

Interactions

Moderate — 1

Potassium Bromide

moderate

Thiazide diuretics increase renal bromide excretion via competitive chloride-bromide transport, reducing bromide levels.

Management: Monitor bromide levels when adding diuretics. Adjust bromide dose to maintain therapeutic range.

Educational reference only

Brands

Other markets

Diuril

FAQs

Frequently asked questions

›What is Chlorothiazide?

Chlorothiazide is a thiazide diuretic used in pets. Inhibits Na+/Cl- cotransporter in the distal convoluted tubule, reducing sodium and chloride reabsorption and promoting diuresis. Also causes mild vasodilation and reduces renal calcium excretion (useful in hypercalciuria).

›What is Chlorothiazide used for in pets?

Chlorothiazide is used in veterinary medicine for: Used for edema, mild CHF (adjunct to furosemide for diuretic resistance — sequen; Used adjunctively with furosemide for diuretic resistance and for calcium oxalat.

›What is the Chlorothiazide dose for dogs?

For dogs, Chlorothiazide is typically dosed as follows — Used for edema, mild CHF (adjunct to furosemide for diuretic resistance — sequen: 20–40 mg/kg PO/IV q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Chlorothiazide dose for cats?

For cats, Chlorothiazide is typically dosed as follows — Used adjunctively with furosemide for diuretic resistance and for calcium oxalat: 10–20 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Chlorothiazide need a prescription?

Yes. Chlorothiazide is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Thiazide Diuretic).

Hydrochlorothiazide

Inhibits sodium and chloride reabsorption in the distal convoluted tubule, promoting diuresis and reducing blood pressure

dogcat