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Chlorhexidine

CDSCO approved
Antiseptic / Disinfectant (Biguanide)
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
2

Mechanism of action

Disrupts bacterial cell membranes by binding to negatively charged cell wall components, causing cell lysis; effective against gram-positive and gram-negative bacteria and some fungi

At a glance

Class
Antiseptic / Disinfectant (Biguanide)
Schedule
OTC
Storage
Store at room temperature
CDSCO (India)
Vet-approved — 1975-01

Dosing

🐕

Dog

Skin infections / Wound lavage / Shampoo therapy
Dose
0.05 %
Route
Topical
Frequency
BID to TID (wound) or 2–3× weekly (shampoo)
Max dose
0 mg
Duration: Until infection resolves
🐈

Cat

Skin infections / Wound lavage
Dose
0.05 %
Route
Topical
Frequency
BID to TID
Max dose
0 mg
Duration: Until infection resolves
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

🧴

Solution — 1

Strength
2% concentrate
Available in India
💊

Shampoo — 1

Strength
2–4%
Available in India

Storage

Store at room temperature

Safety

Absolute contraindications — do not use

  • Contact with eyes, ears (ototoxic), or CNS tissue
    Can cause corneal damage and ototoxicity

Use with caution

  • Open body cavities
    Use dilute solutions only

Adverse effects

Common
Mild skin irritation
Dryness with repeated use
Serious
Ototoxicity (if enters middle ear)
Corneal ulceration (if contacts eye)

Monitoring parameters

Skin conditionAvoid contact with eyes and ears
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

International

Nolvasan
Zoetis

India

Hexidine
ICPA Health Products
Chlorhex
Himalaya

FAQs

Frequently asked questions

What is Chlorhexidine?
Chlorhexidine is a antiseptic / disinfectant (biguanide) used in pets. Disrupts bacterial cell membranes by binding to negatively charged cell wall components, causing cell lysis; effective against gram-positive and gram-negative bacteria and some fungi
What is Chlorhexidine used for in pets?
Chlorhexidine is used in veterinary medicine for: Skin infections / Wound lavage / Shampoo therapy; Skin infections / Wound lavage.
What is the Chlorhexidine dose for dogs?
For dogs, Chlorhexidine is typically dosed as follows — Skin infections / Wound lavage / Shampoo therapy: 0.05 % Topical BID to TID (wound) or 2–3× weekly (shampoo). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Chlorhexidine dose for cats?
For cats, Chlorhexidine is typically dosed as follows — Skin infections / Wound lavage: 0.05 % Topical BID to TID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What are the side effects of Chlorhexidine?
Common: Mild skin irritation, Dryness with repeated use. Serious (call your vet immediately): Ototoxicity (if enters middle ear), Corneal ulceration (if contacts eye).
Does Chlorhexidine need a prescription?
Chlorhexidine is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
When should Chlorhexidine not be used?
Do not use Chlorhexidine if: Contact with eyes, ears (ototoxic), or CNS tissue.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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