Veterinary-specific third-generation cephalosporin with broad gram-negative spectrum including Pasteurella, E. coli, Salmonella, and Klebsiella. Active metabolite desfuroylceftiofur retains antibacterial activity. FDA-approved for dogs.
At a glance
Class
Third-Generation Cephalosporin (Veterinary)
Storage
Powder at room temperature; reconstituted refrigerated, use within 12h (Naxcel) or 7 days (Excenel)
Dosing
FDA-approved for canine UTIs caused by susceptible E
Off-label for feline infections
Safety
Culture and sensitivityClinical responseInjection site
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Ceftiofur Sodium?
Ceftiofur Sodium is a third-generation cephalosporin (veterinary) used in pets. Veterinary-specific third-generation cephalosporin with broad gram-negative spectrum including Pasteurella, E. coli, Salmonella, and Klebsiella. Active metabolite desfuroylceftiofur retains antibacterial activity. FDA-approved for dogs.
›What is Ceftiofur Sodium used for in pets?
Ceftiofur Sodium is used in veterinary medicine for: FDA-approved for canine UTIs caused by susceptible E; Off-label for feline infections.
›What is the Ceftiofur Sodium dose for dogs?
For dogs, Ceftiofur Sodium is typically dosed as follows — FDA-approved for canine UTIs caused by susceptible E: 2.2 mg/kg SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Ceftiofur Sodium dose for cats?
For cats, Ceftiofur Sodium is typically dosed as follows — Off-label for feline infections: 2.2 mg/kg SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Ceftiofur Sodium need a prescription?
Yes. Ceftiofur Sodium is a prescription medication and should only be administered under veterinary supervision.
References
CDSCO approvals (India) — 6
Ceftiofur Sodium Inj
M/s Aurobindo Pharma · Approved 08.10.2002
For treatment of bovine respiratory diease acute bovine interdigital necrobacillosis, bacterial respiratory disease in s
Ceftiofur hcl liquid sterile suspension
M/s Aurobindo Pharma · Approved 08.10.2002
For treatment and control of swine and bovine bacterial respiratory disease
Ceftiofur sod. Inj
M/s Alembic Limited · Approved 12.10.2004
Additional lower strenght.
Ceftiofur Crystalline free acid suspension equi to Ceftiofur--- 200 mg vet
M/s Pfizer Ltd, Mumbai · Approved 01.10.2008
For treatment of bovine respiratory Disease BRD shipping fever pneumonia associated with Mannheimia Haemolytica Pasteure
Ceftiofur HCI Suspension as HCI salt ---500 mg vet
M/s Pfizer Ltd, Mumbai · Approved 01.10.2008
For treatment of clinical mastitis in lactating dairy cattle associated with coagulase-negative staphylococci, Streptoco
Ceftiofur HCI Suspension as HCI salt ---125 mg vet
M/s Pfizer Ltd, Mumbai · Approved 01.10.2008
For treatment of clinical mastitis in lactating dairy cattle associated with coagulase-negative staphylococci, Streptoco
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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