Liposomal encapsulation of bupivacaine that provides sustained drug release over 72h from a single injection, blocking voltage-gated sodium channels and preventing pain signal transmission for significantly longer than standard bupivacaine (4–8h).
At a glance
Class
Extended-Release Local Anesthetic
Storage
Refrigerate 2–8°C; can be at room temperature up to 30 days; do not freeze; gently invert to mix — do not shake
Dosing
FDA-approved for post-operative analgesia at surgical sites in dogs
Frequency
Once per surgical site
FDA-approved for cats (onychectomy/declaw — where still performed)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Pain scores for 72h post-surgerySurgical site healingSigns of systemic toxicity
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Bupivacaine Liposome?
Bupivacaine Liposome is a extended-release local anesthetic used in pets. Liposomal encapsulation of bupivacaine that provides sustained drug release over 72h from a single injection, blocking voltage-gated sodium channels and preventing pain signal transmission for significantly longer than standard bupivacaine (4–8h).
›What is Bupivacaine Liposome used for in pets?
Bupivacaine Liposome is used in veterinary medicine for: FDA-approved for post-operative analgesia at surgical sites in dogs; FDA-approved for cats (onychectomy/declaw — where still performed).
›What is the Bupivacaine Liposome dose for dogs?
For dogs, Bupivacaine Liposome is typically dosed as follows — FDA-approved for post-operative analgesia at surgical sites in dogs: 5.3 mg/kg PO Once per surgical site. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Bupivacaine Liposome dose for cats?
For cats, Bupivacaine Liposome is typically dosed as follows — FDA-approved for cats (onychectomy/declaw — where still performed): 5.3 mg/kg Local infiltration Once. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Bupivacaine Liposome need a prescription?
Yes. Bupivacaine Liposome is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database