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Azithromycin Ophthalmic

Prescription
Ophthalmic Macrolide Antibiotic
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
1

Mechanism of action

Macrolide antibiotic in a polycarbophil mucoadhesive vehicle (DuraSite) that adheres to the ocular surface, providing sustained drug release. Binds 50S ribosomal subunit inhibiting protein synthesis. Also has anti-inflammatory properties.

At a glance

Class
Ophthalmic Macrolide Antibiotic
Schedule
Prescription
Storage
Store at room temperature; discard 14 days after opening

Dosing

🐕

Dog

Used for bacterial conjunctivitis, blepharitis, and Meibomian gland disease
Dose
Route
Ophthalmic
Frequency
q12–24h (see protocol)
🐈

Cat

NOT effective against Chlamydophila felis (intracellular — needs systemic doxycy
Dose
Route
Ophthalmic
Frequency
q12–24h

Formulations

💊

Other — 1

Strength

Storage

Store at room temperature; discard 14 days after opening

Safety

Monitoring parameters

Clinical response at 5–7 daysCulture if no improvement

Interactions

No documented interactions.

Brands

United States

AzaSite
InSite Vision

FAQs

Frequently asked questions

What is Azithromycin Ophthalmic?
Azithromycin Ophthalmic is a ophthalmic macrolide antibiotic used in pets. Macrolide antibiotic in a polycarbophil mucoadhesive vehicle (DuraSite) that adheres to the ocular surface, providing sustained drug release. Binds 50S ribosomal subunit inhibiting protein synthesis. Also has anti-inflammatory properties.
What is Azithromycin Ophthalmic used for in pets?
Azithromycin Ophthalmic is used in veterinary medicine for: Used for bacterial conjunctivitis, blepharitis, and Meibomian gland disease; NOT effective against Chlamydophila felis (intracellular — needs systemic doxycy.
What is the Azithromycin Ophthalmic dose for dogs?
For dogs, Azithromycin Ophthalmic is typically dosed as follows — Used for bacterial conjunctivitis, blepharitis, and Meibomian gland disease: undefined undefined Ophthalmic q12–24h (see protocol). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Azithromycin Ophthalmic dose for cats?
For cats, Azithromycin Ophthalmic is typically dosed as follows — NOT effective against Chlamydophila felis (intracellular — needs systemic doxycy: undefined undefined Ophthalmic q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Azithromycin Ophthalmic need a prescription?
Yes. Azithromycin Ophthalmic is a prescription medication and should only be administered under veterinary supervision.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →