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Amprolium

Anticoccidial (Thiamine Analog)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
3

Mechanism of action

Structural analog of thiamine (vitamin B1) that competitively inhibits thiamine uptake by coccidia, disrupting their carbohydrate metabolism and energy production. Selectively toxic to coccidia because they require exogenous thiamine.

At a glance

Class
Anticoccidial (Thiamine Analog)
Schedule
OTC
Storage
Store at room temperature, protect from moisture

Dosing

🐕

Dog

Used for Isospora (Cystoisospora) coccidiosis in puppies and dogs
Dose
110–220 mg/kg
Route
PO
Frequency
q24h
🐈

Cat

Off-label for feline coccidiosis
Dose
110–220 mg/kg
Route
PO
Frequency
q24h

Formulations

💊

Other — 3

Strength
Strength
Strength

Storage

Store at room temperature, protect from moisture

Safety

Monitoring parameters

Fecal examination for oocysts post-treatmentNeurological signs (thiamine deficiency)Clinical improvement

Interactions

No documented interactions.

Brands

Other markets

Corid
Amprovine

FAQs

Frequently asked questions

What is Amprolium?
Amprolium is a anticoccidial (thiamine analog) used in pets. Structural analog of thiamine (vitamin B1) that competitively inhibits thiamine uptake by coccidia, disrupting their carbohydrate metabolism and energy production. Selectively toxic to coccidia because they require exogenous thiamine.
What is Amprolium used for in pets?
Amprolium is used in veterinary medicine for: Used for Isospora (Cystoisospora) coccidiosis in puppies and dogs; Off-label for feline coccidiosis.
What is the Amprolium dose for dogs?
For dogs, Amprolium is typically dosed as follows — Used for Isospora (Cystoisospora) coccidiosis in puppies and dogs: 110–220 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Amprolium dose for cats?
For cats, Amprolium is typically dosed as follows — Off-label for feline coccidiosis: 110–220 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Amprolium need a prescription?
Amprolium is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.

References

CDSCO approvals (India) — 1

Amprolium HCl IP 16.67% w/w Sulfaquinoxaline IP 16.67% w/w Powder (veterinary pr
M/s. Vibro Pharma · Approved 03.02.2017
For the treatment of Coccidiosis in poultry
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Related medicines

Other medicines in the same class (Anticoccidial).

Decoquinate
Inhibits electron transport in coccidial mitochondria, blocking sporozoite development. Coccidiostatic — prevents replication but does not kill existing organisms. Used prophylactically, not therapeutically.
dogcat