Amoxicillin inhibits bacterial cell wall synthesis by binding PBPs. Clavulanate irreversibly inhibits bacterial beta-lactamases, protecting amoxicillin from enzymatic degradation and extending spectrum to beta-lactamase-producing organisms.
At a glance
Class
Beta-Lactam / Beta-Lactamase Inhibitor Combination
Storage
Tablets at room temperature; oral drops refrigerated after reconstitution, discard after 10 days
Dosing
First-line empiric antibiotic for skin infections, UTIs, bite wounds, and respir
First-line for feline UTI, skin infections, bite wound abscesses, and upper resp
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Clinical response at 3–5 daysGI toleranceCulture and sensitivity for refractory cases
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Amoxicillin/Clavulanate?
Amoxicillin/Clavulanate is a beta-lactam / beta-lactamase inhibitor combination used in pets. Amoxicillin inhibits bacterial cell wall synthesis by binding PBPs. Clavulanate irreversibly inhibits bacterial beta-lactamases, protecting amoxicillin from enzymatic degradation and extending spectrum to beta-lactamase-producing organisms.
›What is Amoxicillin/Clavulanate used for in pets?
Amoxicillin/Clavulanate is used in veterinary medicine for: First-line empiric antibiotic for skin infections, UTIs, bite wounds, and respir; First-line for feline UTI, skin infections, bite wound abscesses, and upper resp.
›What is the Amoxicillin/Clavulanate dose for dogs?
For dogs, Amoxicillin/Clavulanate is typically dosed as follows — First-line empiric antibiotic for skin infections, UTIs, bite wounds, and respir: 12.5–25 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Amoxicillin/Clavulanate dose for cats?
For cats, Amoxicillin/Clavulanate is typically dosed as follows — First-line for feline UTI, skin infections, bite wound abscesses, and upper resp: 12.5 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Amoxicillin/Clavulanate need a prescription?
Yes. Amoxicillin/Clavulanate is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database