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Amoxicillin + Clavulanate

PrescriptionCDSCO approved
Beta-lactam antibiotic + beta-lactamase inhibitor
Last reviewed 18 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
4 available
Formulations
4

Mechanism of action

Amoxicillin inhibits bacterial cell wall synthesis; clavulanate inhibits beta-lactamase enzymes, extending spectrum to resistant organisms

At a glance

Class
Beta-lactam antibiotic + beta-lactamase inhibitor
Schedule
Prescription
Storage
Store below 25°C. Reconstituted suspension: refrigerate, use within 7 days
CDSCO (India)
Vet-approved — 1987-10

Dosing

🐕

Dog

Skin and soft tissue infections
Dose
12.5–25 mg/kg
Route
PO
Frequency
BID
Max dose
625 mg/dose; 1250 mg/day
Duration: 7-14 days
Urinary tract infections
Dose
12.5–25 mg/kg
Route
PO
Frequency
BID
Max dose
625 mg/dose; 1250 mg/day
Duration: 10-14 days
Dental infections
Dose
12.5–25 mg/kg
Route
PO
Frequency
BID
Max dose
625 mg/dose; 1250 mg/day
Duration: 7-10 days
🐈

Cat

Skin and soft tissue infections
Dose
12.5–25 mg/kg
Route
PO
Frequency
BID
Max dose
312.5 mg/dose; 625 mg/day
Duration: 7-14 days
Urinary tract infections
Dose
12.5–25 mg/kg
Route
PO
Frequency
BID
Max dose
312.5 mg/dose; 625 mg/day
Duration: 10-14 days
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Tablet — 2

Strength
228.5mg
Available in India
Strength
457mg
Available in India
🧴

Suspension — 1

Strength
228.5mg/5mL
Available in India
💉

Injectable — 1

Strength
600mg vial
Available in India

Storage

Store below 25°C. Reconstituted suspension: refrigerate, use within 7 days

Safety

Absolute contraindications — do not use

  • Known penicillin hypersensitivity
    Cross-reactivity with other beta-lactams possible

Use with caution

  • Renal impairment
    Dose adjustment required in severe renal failure
  • Concurrent methotrexate
    Reduced methotrexate clearance

Adverse effects

Common
Vomiting
Diarrhoea
Anorexia
Serious
Anaphylaxis
Hepatotoxicity (rare)
Blood dyscrasias

Monitoring parameters

Clinical responseGI toleranceLiver enzymes for prolonged courses
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

International

Synulox
Zoetis
Augmentin
GSK

India

Clavam
Alkem
Moxikind-CV
Mankind

FAQs

Frequently asked questions

What is Amoxicillin + Clavulanate?
Amoxicillin + Clavulanate is a beta-lactam antibiotic + beta-lactamase inhibitor used in pets. Amoxicillin inhibits bacterial cell wall synthesis; clavulanate inhibits beta-lactamase enzymes, extending spectrum to resistant organisms
What is Amoxicillin + Clavulanate used for in pets?
Amoxicillin + Clavulanate is used in veterinary medicine for: Skin and soft tissue infections; Urinary tract infections; Dental infections.
What is the Amoxicillin + Clavulanate dose for dogs?
For dogs, Amoxicillin + Clavulanate is typically dosed as follows — Skin and soft tissue infections: 12.5–25 mg/kg PO BID; Urinary tract infections: 12.5–25 mg/kg PO BID; Dental infections: 12.5–25 mg/kg PO BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Amoxicillin + Clavulanate dose for cats?
For cats, Amoxicillin + Clavulanate is typically dosed as follows — Skin and soft tissue infections: 12.5–25 mg/kg PO BID; Urinary tract infections: 12.5–25 mg/kg PO BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What are the side effects of Amoxicillin + Clavulanate?
Common: Vomiting, Diarrhoea, Anorexia. Serious (call your vet immediately): Anaphylaxis, Hepatotoxicity (rare), Blood dyscrasias.
Does Amoxicillin + Clavulanate need a prescription?
Yes. Amoxicillin + Clavulanate is a prescription medication and should only be administered under veterinary supervision.
When should Amoxicillin + Clavulanate not be used?
Do not use Amoxicillin + Clavulanate if: Known penicillin hypersensitivity.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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