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Ammonium Chloride

Prescription
Urinary Acidifier / Expectorant
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
3

Mechanism of action

Metabolized by the liver, releasing H+ ions (metabolic acidification) and Cl- ions. The excess H+ is excreted renally, acidifying urine. Used to dissolve struvite uroliths (which form in alkaline urine) and to treat metabolic alkalosis.

At a glance

Class
Urinary Acidifier / Expectorant
Schedule
Prescription
Storage
Store at room temperature, protect from moisture

Dosing

🐕

Dog

Used for struvite urolith dissolution/prevention (target urine pH 6
Dose
100–200 mg/kg
Route
PO, IV (alkalosis)
Frequency
q12h (PO)
🐈

Cat

Used for struvite prevention in cats
Dose
20–40 mg/kg
Route
PO
Frequency
q12h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 3

Strength
Strength
Strength

Storage

Store at room temperature, protect from moisture

Safety

Monitoring parameters

Urine pH (target 6.0–6.5)Blood gas (metabolic acidosis)Serum electrolytesHepatic function
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

NH4Cl

FAQs

Frequently asked questions

What is Ammonium Chloride?
Ammonium Chloride is a urinary acidifier / expectorant used in pets. Metabolized by the liver, releasing H+ ions (metabolic acidification) and Cl- ions. The excess H+ is excreted renally, acidifying urine. Used to dissolve struvite uroliths (which form in alkaline urine) and to treat metabolic alkalosis.
What is Ammonium Chloride used for in pets?
Ammonium Chloride is used in veterinary medicine for: Used for struvite urolith dissolution/prevention (target urine pH 6; Used for struvite prevention in cats.
What is the Ammonium Chloride dose for dogs?
For dogs, Ammonium Chloride is typically dosed as follows — Used for struvite urolith dissolution/prevention (target urine pH 6: 100–200 mg/kg PO/IV (alkalosis) q12h (PO). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Ammonium Chloride dose for cats?
For cats, Ammonium Chloride is typically dosed as follows — Used for struvite prevention in cats: 20–40 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Ammonium Chloride need a prescription?
Yes. Ammonium Chloride is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

CDSCO approvals (India) — 1

Disinfectant Glutaraldehyde +Didecyl Dimethyl Ammonium Chloride + Ethylene Dioxy
M/s Gopaldas Visram & co. Ltd., · Approved 09.07.2021
Liquid Concentrate Having Broad Spectrum Bactericidal, Sporicidal, Fungicidal andvircidal properties for use in poultry
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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