Synthetic steroid that competitively antagonizes progesterone at its receptor with ~3x higher affinity than progesterone itself. Blocks progesterone's actions on the uterus and mammary gland, causing pregnancy termination and treating pyometra/false pregnancy.
At a glance
Class
Progesterone Receptor Antagonist
Storage
Store at 2–8°C; bring to room temperature before injection; stable 30 days at room temperature
Dosing
EU-licensed for pregnancy termination and medical management of pyometra in dogs
Frequency
Per indication (see notes)
Off-label in cats
Frequency
Days 1 and 2 (per indication)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Pregnancy termination confirmed by ultrasound 10 days post-treatmentUterine drainage character and volume (pyometra)Serial CBC and biochemistry (pyometra cases)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Aglepristone?
Aglepristone is a progesterone receptor antagonist used in pets. Synthetic steroid that competitively antagonizes progesterone at its receptor with ~3x higher affinity than progesterone itself. Blocks progesterone's actions on the uterus and mammary gland, causing pregnancy termination and treating pyometra/false pregnancy.
›What is Aglepristone used for in pets?
Aglepristone is used in veterinary medicine for: EU-licensed for pregnancy termination and medical management of pyometra in dogs; Off-label in cats.
›What is the Aglepristone dose for dogs?
For dogs, Aglepristone is typically dosed as follows — EU-licensed for pregnancy termination and medical management of pyometra in dogs: undefined undefined SQ Per indication (see notes). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Aglepristone dose for cats?
For cats, Aglepristone is typically dosed as follows — Off-label in cats: 15 mg/kg SQ Days 1 and 2 (per indication). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Aglepristone need a prescription?
Yes. Aglepristone is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 1
Aglepristone 30mg/ml solution for injection for Veterinary use (Alizin )
M/s Virbac Animal Health India pvt ltd · Approved 21.01.2022
Dogs: (Pregnant bitches) for the induction of abortion up to 45 days after mating.
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database